Carboxypeptidase A has esterase activity as well as peptidase activity, so it can hydrolyze ester bonds as well as peptide bonds. When carboxypeptidase A hydrolyzes ester bonds, Glu 270 acts as a nucleophilic catalyst instead of a general-base catalyst. Propose a mechanism for the carboxypeptidase A–catalyzed hydrolysis of an ester bond.
Carboxypeptidase A has esterase activity as well as peptidase activity, so it can hydrolyze ester bonds as well as peptide bonds. When carboxypeptidase A hydrolyzes ester bonds, Glu 270 acts as a nucleophilic catalyst instead of a general-base catalyst. Propose a mechanism for the carboxypeptidase A–catalyzed hydrolysis of an ester bond.
Chapter22: Carbonyl Alpha-substitution Reactions
Section22.SE: Something Extra
Problem 30MP: One of the later steps in glucose biosynthesis is the isomerization of fructose 6-phosphate to...
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Carboxypeptidase A has esterase activity as well as peptidase activity, so it can hydrolyze ester bonds as well as peptide bonds. When carboxypeptidase A hydrolyzes ester bonds, Glu 270 acts as a nucleophilic catalyst instead of a general-base catalyst. Propose a mechanism for the carboxypeptidase A–catalyzed hydrolysis of an ester bond.
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