Certain individuals with mild forms ofβ-thalassemia produce, in addition to normal adulthemoglobin with two α chains and two β chains,lower levels of an unusual, so-called Leporehemoglobin with two α chains and two chains ineach of which the N-terminal half comes from anormal δ chain and the C-terminal half comesfrom a normal β chain. Certain other individualswho are asymptomatic produce a different, unusualanti-Lepore hemoglobin that contains two α chainsand two chains in which the N-terminal half comesfrom a normal β chain and the C-terminal halfcomes from a normal δ chain.a. Describe an event that could give rise to bothLepore and anti-Lepore hemoglobins

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Certain individuals with mild forms of
β-thalassemia produce, in addition to normal adult
hemoglobin with two α chains and two β chains,
lower levels of an unusual, so-called Lepore
hemoglobin with two α chains and two chains in
each of which the N-terminal half comes from a
normal δ chain and the C-terminal half comes
from a normal β chain. Certain other individuals
who are asymptomatic produce a different, unusual
anti-Lepore hemoglobin that contains two α chains
and two chains in which the N-terminal half comes
from a normal β chain and the C-terminal half
comes from a normal δ chain.
a. Describe an event that could give rise to both
Lepore and anti-Lepore hemoglobins

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