COO COO Co, CH, CH, CH, CH, C=0 C=0 CoO H a-Ketoglutarate Succinate semialdehyde (a) Succinate semialdehyde is then converted to succinate, which is further metabolized by standard citric acid cycle enzymes. What kind of reac- tion is required to convert succinate semialdehyde to succinate? Show any coenzymes that might be involved. (b) Based on your answer in part a, how does this pathway compare to the standard citric acid cycle in energy yield?

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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Certain microorganisms with a modified citric acid cycle decarboxylate α-ketoglutarate to produce succinate semialdehyde:

COO
COO
Co,
CH,
CH,
CH,
CH,
C=0
C=0
CoO
H
a-Ketoglutarate
Succinate semialdehyde
(a) Succinate semialdehyde is then converted to succinate, which is further
metabolized by standard citric acid cycle enzymes. What kind of reac-
tion is required to convert succinate semialdehyde to succinate? Show
any coenzymes that might be involved.
(b) Based on your answer in part a, how does this pathway compare to the
standard citric acid cycle in energy yield?
Transcribed Image Text:COO COO Co, CH, CH, CH, CH, C=0 C=0 CoO H a-Ketoglutarate Succinate semialdehyde (a) Succinate semialdehyde is then converted to succinate, which is further metabolized by standard citric acid cycle enzymes. What kind of reac- tion is required to convert succinate semialdehyde to succinate? Show any coenzymes that might be involved. (b) Based on your answer in part a, how does this pathway compare to the standard citric acid cycle in energy yield?
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