Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to behave as a recessive gene?

Q: Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb?  If so, how…

A: The process by which a cell gives rise to two identical daughter cells is referred to as cell…

Q: Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and…

A: Normal cell has low level of p53 protein. When DNA damage or other stress signals may trigger p53…

Q: Which of the following statements about tumor suppressor genes is FALSE? a) Inactivation of tumor…

A: False statement about tumor suppressor genes.

Q: ___________ are changes to the order of nucleotides in a segment of DNA that codes for a protein. a.…

A: Nucleotide is the basic building block of nucleic acids. RNA and DNA are long chains of nucleotides.…

Q: A normally functioning gene that regulates the cell cycle by stopping cell division is most likely…

A: Question - A normally functioning gene that regulates the cell cycle by stopping cell division is…

Q: Describe three common ways that tumor-suppressor genes aresilenced.

A: Tumour suppressor genes are genes that can decrease the rate of cell division and growth. In the…

Q: Distinguish between proto-oncogenes and tumor suppressor genes?

A: The proto-oncogenes are those genes, which promote the cell cycle and inhibit apoptosis of the…

Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…

A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…

Q: Which of the following mutations is MOST likely to cause cancer? A) a mutation that causes a cyclin…

A: Introduction- Cancer is a caused by the disturbances in the  controls which regulate cells and this…

Q: The p53 gene encodes a tumor-suppressor protein, p53, which acts as a transcription factor for…

A: Answer. Genes for which a gain of function mutation drives a cell towards cancer are called proto…

Q: Explain the role of epigenetic alterations in cancer ?

A: Genes are the hereditary unit in an organism and are passed on from the parental generation to the…

Q: Explain how mutations in oncogenes and in tumor suppressorgenes cause cancer.

A: Cancer is a group of diseases that involves abnormal growth of the cell. These cells have the…

Q: Describe three popular methods for silencing tumor-suppressor genes.

A: Introduction Tumor suppressor genes are those that slow down the division and development of cells.…

Q: Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene…

A: Tumor-supressor genes: Tumor-suppressor genes is defined as normal genes that will slow down the…

Q: What is the difference between an oncogene and a tumor-suppressorgene? Give two examples of each…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: Compare and contrast oncogenes and tumor suppressor genes.

A: Oncogenes are those genes that have the potential to cause cancer. These genes are often mutated or…

Q: Which of the following is not a tumor suppressor gene? a.RET b.RB c.BRCA1 d.BRCA2

A: A normal cell undergoes regulated division, differentiation, and apoptosis (programmed cell death).…

Q: The normal copies of tumor-suppressor genes encode proteins that have which three types of…

A: A tumour suppressor gene also known as anti-oncogene is a gene that is responsible to regulate the…

Q: Explain about the Cancer-causing gene formed by a mutation in a proto-oncogene ?

A: In genetics, the mutation is defined as the changes or alteration in the DNA sequences which result…

Q: Describe how tumor suppressors function to stop the cell cycle until certain events are completed

A: Normal genes that delay cell division, repair DNA errors, or tell cells when to die are known as…

Q: Describe the differences between point mutations, chromosomal translocations, and gene amplification…

A: Cancer is a disease that is associated with the uncontrolled division of cells and invasion of…

Q: Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had…

A: BRCA1 is a tumor suppressor gene usually expressed in breast cells. It is responsible for repairing…

Q: Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do…

A: Oncogene is a type of gene having the ability which can develop a cell to a tumor cell when…

Q: In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an…

A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…

Q: Describe the underlying causes of epigenetic changes associated with cancer.

A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…

Q: Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote…

A: It codes for a protein or a functional product rRNA (ribosomal RNA) or tRNA (transfer RNA). DNA is…

Q: Which type of mutation would NOT be involved in the inactivation of a tumor suppressor gene?

A: Normal cell growth in body is controlled by -  1. Protooncogene or cellular oncogene - Protooncogene…

Q: Most forms of cancer involvea. the activation of a single oncogene.b. the inactivation of a single…

A: The medical condition of cancer is characterized by the abnormal growth pattern of the cells…

Q: Products of proto-oncogenes and tumor-suppressor genes can be     growth factors and growth factor…

A: Normal DNA contains a particular sequence of DNA. If the sequence of DNA is changed due to external…

Q: Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene…

A: An oncogene helps in control cell division and  contributes to cancer progression whereas a tumor…

Q: Explain the normal regulation of proto-oncogenes and tumor suppressor genes that prevents cells from…

A: Oncogenes and tumour suppressor genes are two types of genes that relate cell cycle regulation to…

Q: Which of the following is not an example of tumor-suppressor gene? A. p53 gene B. Rb…

A: p53 gene It is a tumor suppressor gene It's activity stops the formation of tumors It is located…

Q: Apart from p53, mention and describe the function of three tumor suppressor genes you know

A: The cancer related genes can be divided into two broad categories like the proto-oncogenes and tumor…

Q: Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a)…

A: Cells that progress through the cell cycle unchecked may sequentially develop malignant tumors.…

Q: Explain how epigenetic changes can contribute to tumorigenesis.

A: Tumors are clumps of cells formed by uncontrollable cell division. Tumorigenesis is the uncontrolled…

Q: n of tu

A: Tumour suppressor genes can be defined as the gene that is involved in the regulation and…

Q: Compare and contrast oncogenes versus tumor-suppressorgenes.

A: Cancer is the uncontrolled proliferation of cells that can be treated by chemotherapy and…

Q: Why are oncogenes usually dominant in their action, whereas tumor-suppressor genes are recessive?

A: BASIC INFORMATION ONCOGENES When there is alteration in the proto-onco genes then it leads to the…

Q: How do BRCA1 and BRCA2 function in regard to cell proliferation (are they proto-oncogenes,…

A: jjBRCA proteins play an important role in a variety of biological functions. In response to DNA…

Q: Explain Mutations in tumor-suppressor genes are recessive at the cellular level but dominant at the…

A: Cancer is a group of diseases involving abnormal growth of cells, which tend to proliferate in an…

Q: What is the role of regulatory gene mutations in cancer?

A: Regulatory genes are defined as genes which control or regulate the expression of one or multiple…

Q: Describe how the tumor-suppressor genes Rb, p53 and p21 regulate the cell cycle.

A: Tumor suppressor gene  These gene controls the activity of cell division cycles. They decide whether…

Q: Would a drug that induced apoptosis or one that induced necrosis be preferable for treatment of…

A: INTRODUCTION Flowcytometry Flowcytometry is a technique that simultaneously measures and analyse…

Q: Explain the difference between a proto-oncogene and a tumor-suppressor gene.

A: Cancer is the state of uncontrolled cell division.

Q: Discuss the challenges of producing anticancer drugs that counteract the effects of mutations in…

A: Tumor suppressor genes are the genes that decline the cell division process, acts in programmed cell…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.