Describe the experiment done by Frederick Griffith in 1928, where the non-lethal (rough) strain of Streptococcus pneumoniae bacteria killed experimental mice when mixed with the heat-killed smooth strain. Discuss what may have happened to the rough strain after the heat-killed smooth strain was introduced and why you think the rough strain killed the mice. What

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Describe the experiment done by Frederick Griffith in 1928, where the non-lethal (rough) strain of Streptococcus pneumoniae bacteria killed experimental mice when mixed with the heat-killed smooth strain. Discuss what may have happened to the rough strain after the heat-killed smooth strain was introduced and why you think the rough strain killed the mice. What would be the conclusion and significance of this study and its finding?
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Step 1

Frederick Griffith  was a British bacteriologist.He was a physician, pathologist and a bacteriologist.Frederick Griffith was born in Prescot,Merseyside , England.He presented Griffith experiment in January 1928.

Step 2

Griffith experiment was the first experiment which suggested that bacteria are able to transfer genetic material through a process called transformation.

Griffith used two strains of pneumococcus bacteria:

  • Smooth strain:Virulent and produced a polysaccharide capsule for protection of itself from immune system of host
  • Rough strain-non virulent and did not have any protective capsule and hence no protection from immune system of host

So steps in the experiment of Griffith are:

  • S strain bacteria injected into mice and mice died
  • R strain injected into mice and no death of mice
  • When Griffith injected heat killed S into mice ,no death occurred
  • When mixture of heat killed S and live R was injected,death occurred
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