Asked Oct 26, 2019

describe the normal and abnormal metabolic pathways of COPD and describe why/how they are disrupted.


Expert Answer

Step 1

COPD (chronic obstructive pulmonary disease) is a lung syndrome that includes both bronchitis (inflammation of bronchial tubes) and emphysema (damaged air sacs). This condition is incurable and damaged lung cannot be reversed back to normal condition.

Step 2

In the metabolic pathway of COPD, it triggers the increase in tumor necrosis factor-alpha (TNFα). An increase in TNFα leads to 3 effects involving decreased anabolism, increased reactive oxygen species and increased catabolism of necrosis factor that contribute to decreasing in contractile proteins that cause muscle wasting.


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Pahuway of Copn COPD TNF 1 Anabolsm Dawage Catabolism J Trackive Nk Anoreia ubn eenislomce Reactire Speues (Ros) atein Sytless Degadahin CUMipatin Acive es e NrG Conkachle tems Neeko memdrae APrtease mRNAlo contractile ptein NFK3 Lnde phr selgn

Step 3

Metabolic abnormalities in the pathway of COPD include an increase in fat mass and loss of muscle mass as depicted in t...

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