Describe the underlying causes of epigenetic changes associated with cancer.

Q: What is the link between epigenetics and cancer?

A: Epigenetics is considered as the study in which the gene shows its behavior according to the…

Q: How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the…

A: Epigenetics is the study of various alterations in an organism occurred because of certain gene…

Q: Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to…

A: The repeated and uncontrollable division of cells forms a large mass called the tumor. Tumors might…

Q: Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and…

A: Normal cell has low level of p53 protein. When DNA damage or other stress signals may trigger p53…

Q: Genes that cause cancer are called _____________.

A: Cancer means uncontrol cell proliferation and division in the body. This uncontrolled group of cell…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Medical technology has advanced significantly over the course of many centuries. According to…

Q: Explain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause…

A: A tumor suppressor gene is normally a cellular gene that regulates the cell proliferation or DNA…

Q: What significance do BRCA1 and BRCA2 have in regard to developing cancer, and what types of cancer…

A: BRCA 1 & BRCA 2 are found pair in all the organisms where one gene is obtained from each of the…

Q: Distinguish between proto-oncogenes and tumor suppressor genes?

A: The proto-oncogenes are those genes, which promote the cell cycle and inhibit apoptosis of the…

Q: Explain why mutations in tumor suppressor genes are recessive (both copies of the gene must be…

A: Mutation in an organism is defined as a permanent alteration of “nucleotide sequences”. The…

Q: Explain how Epigenetics are related with Cancer ?

A: Answer- Epigenetics is the change in the gene expression without changing the sequence of the DNA.

Q: Explain the role of epigenetic alterations in cancer ?

A: Genes are the hereditary unit in an organism and are passed on from the parental generation to the…

Q: Explain how mutations in oncogenes and in tumor suppressorgenes cause cancer.

A: Cancer is a group of diseases that involves abnormal growth of the cell. These cells have the…

Q: Describe epigenetic alterations .

A: Epigenetic is defined as the study of heritable chemical Modification of DNA or chromatin that does…

Q: Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene…

A: Tumor-supressor genes: Tumor-suppressor genes is defined as normal genes that will slow down the…

Q: Describe the genetic changes that inactivate tumor-suppressor genes.

A: Cancer is a condition of uncontrolled cell division which results in the formation of tumor. This is…

Q: Describe the characteristics of cancer, and explain the mechanism of transformation.

A: The main fundamental characteristic of cancer cells is the formation of a tumor colony from a single…

Q: Define the relation between DNA Methylation and Cancer ?

A: Cancer is a disorder caused by uncontrolled cell division.

Q: Explain about the Cancer-causing gene formed by a mutation in a proto-oncogene ?

A: In genetics, the mutation is defined as the changes or alteration in the DNA sequences which result…

Q: Explain what is fundamental aberrations in all cancer cells ?

A: Answer: Introduction: The features of chromosomal aberrations in cancers, has studied in the 15,000…

Q: Describe cancer cell types and the differentiation process that occurs during cancer development.

A: Cancer cells are very notorious for causing high Morbidity and mortality among patients of various…

Q: Describe the differences between point mutations, chromosomal translocations, and gene amplification…

A: Cancer is a disease that is associated with the uncontrolled division of cells and invasion of…

Q: How mutations, chromosomal changes epigenetics, and environmental agents play roles in the…

A: Cancer cells breaks the most basic rule of cell behavior by which multicellular organism are built…

Q: Explain what it means when the developmental steps for cancer are “not obligatory” and give one…

A: Cancer is uncontrolled cell division and growth of cells. These tumors eventually start invading…

Q: (a) How does the duplication of individual genes occur? (b) individual that inherit a genetic…

A: Mutation in the DNA can change our genetic material that can causes changes in our phenotype as…

Q: Identify An illness characterized by mutations that disrupt normal control mechanisms and produce…

A: Alterations to the DNA sequence that make up a gene are known as mutations. Environmental influences…

Q: Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote…

A: It codes for a protein or a functional product rRNA (ribosomal RNA) or tRNA (transfer RNA). DNA is…

Q: xplain the molecular mechanisms of cancers caused by a P53 gene mutation.

A: cancer may be a disease during which a number of the body’s cells grow uncontrollably and spread to…

Q: Please distinguish driver and passenger mutations in cancer.

A: Driver mutations: Mutations in known oncogenes that help cells establish or maintain the transformed…

Q: How oncogenes contribute to cancer?

A: Cancer:       It is a disease where cells divide abnormally and damage other cells. There are…

Q: Explain the normal regulation of proto-oncogenes and tumor suppressor genes that prevents cells from…

A: Oncogenes and tumour suppressor genes are two types of genes that relate cell cycle regulation to…

Q: What type of epigenetic changes are associated with cancer?

A: Epigenetic changes or modifications are important for maintenance of tissue specific gene…

Q: What types of evidence indicate that cancer arises from genetic changes?

A: Cancer is a disorder in which abnormal cells divide irrepressibly and destroy the tissues of the…

Q: Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic…

A: A mutation is a form of alteration in which a single change changes a nucleotide of nucleic acid. It…

Q: Describe the difference between a tumor suppressor and an oncogene with respect to the actual causes…

A: Cancer is caused due to the uncontrollable division of cells leading to tumor formation. Genetic…

Q: Explain how epigenetic changes can contribute to tumorigenesis.

A: Tumors are clumps of cells formed by uncontrollable cell division. Tumorigenesis is the uncontrolled…

Q: EXPLAIN BRIEFLY: Explain the molecular mechanisms of cancers caused by a P53 gene mutation.

A: Answers P53 also defined as tumour suppressor Gene. Hence it protect the cells from various damages…

Q: n of tu

A: Tumour suppressor genes can be defined as the gene that is involved in the regulation and…

Q: Explain Mutations in tumor-suppressor genes are recessive at the cellular level but dominant at the…

A: Cancer is a group of diseases involving abnormal growth of cells, which tend to proliferate in an…

Q: Define the following terms: tumor, neoplasia, anaplasia, metastasis, proto-oncogene, oncogene, and…

A: According to the World Health Organization (WHO), cancer is the leading cause of death worldwide.…

Q: What is the role of regulatory gene mutations in cancer?

A: Regulatory genes are defined as genes which control or regulate the expression of one or multiple…

Q: Define telomeres, telomerase, and senescence and describe their effects on cancer.

A: Introduction  Cancer is a disease when a few of the body's cells grow out of control and spread to…

Q: Explain why it usually takes more than one mutation to cause cancer

A: Cancer is a condition wherein a portion of the body's cells develop or grow wildly and can spread to…

Q: Discuss the relationship between cancer and changes in gene expression that affect cell…

A: Cancer is the condition in which the control over the process of cell division is lost.

Q: Explain the difference between a proto-oncogene and a tumor-suppressor gene.

A: Cancer is the state of uncontrolled cell division.

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.