ditions but they are not sure which one. researchers determine the movement of three different ions (sodium, chloride and pot ction of their respective electrochemical gradient across the plasma membrane: Sodium tends to enter the cell Chloride tends to enter the cell Potassium tends to leave the cell researchers therefore propose three simple hypotheses for the effect of cGMP on the ential of the rod photoreceptor cell: ● Hypothesis A: cGMP binds to a sodium-channel, that opens and lets sodium ions d the cell. Hypothesis B: CGMP binds to a chloride-channel, that opens and lets chloride ions the cell. Hypothesis C: CGMP binds to a potassium-channel, that opens and lets potassium outside the cell. se hypotheses and associated experimental setup are depicted in the figure below. pothesis A Inside of the cell CGMP Outside of the cell Nat Na mbrane potential (mv) +50- +30 +10- -10 -30- -50- In the dark (ion channels open)

ditions but they are not sure which one. researchers determine the movement of three different ions (sodium, chloride and pot ction of their respective electrochemical gradient across the plasma membrane: Sodium tends to enter the cell Chloride tends to enter the cell Potassium tends to leave the cell researchers therefore propose three simple hypotheses for the effect of cGMP on the ential of the rod photoreceptor cell: ● Hypothesis A: cGMP binds to a sodium-channel, that opens and lets sodium ions d the cell. Hypothesis B: CGMP binds to a chloride-channel, that opens and lets chloride ions the cell. Hypothesis C: CGMP binds to a potassium-channel, that opens and lets potassium outside the cell. se hypotheses and associated experimental setup are depicted in the figure below. pothesis A Inside of the cell CGMP Outside of the cell Nat Na mbrane potential (mv) +50- +30 +10- -10 -30- -50- In the dark (ion channels open)

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section4.5: Intercellular Communication And Signal Transduction

Problem 3CYU: Outline the three general means by which binding of a water soluble extracellular chemical messenger...

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