Dr. Serena Velazquez lands a coveted post-doc position at Johns Hopkins following completion of her MD/PhD in cancer therapeutics to treat late-stage pancreatic cancer using a mouse model. Her post-doc will be devoted to targeted mutagenesis of replicative enzymes to halt cell division in cancerous cells. She reviews mitosis and meiosis before reporting for her first day of work. 1) If Dr. Velaquez wants to target the replication fork of synthesizing DNA in eukaryotes, what proteins might she consider knocking down to see the effect on cancer progression? a) RPA. b) MCM. c) All the choices are correct. d)Topoisomerase.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter12: Genes And Cancer
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Problem 13QP: The search for the BRCA1 breast cancer gene discussed in this chapter was widely publicized in the...
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Dr. Serena Velazquez lands a coveted post-doc position at Johns Hopkins following completion of her MD/PhD in cancer therapeutics to treat late-stage pancreatic cancer using a mouse model. Her post-doc will be devoted to targeted mutagenesis of replicative enzymes to halt cell division in cancerous cells. She reviews mitosis and meiosis before reporting for her first day of work.
1)
If Dr. Velaquez wants to target the replication fork of synthesizing DNA in eukaryotes, what proteins might she consider knocking down to see the effect on cancer progression?
a) RPA.
b) MCM.
c) All the choices are correct.
d)Topoisomerase.
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