During DNA replication, as DNA unwinds it can become supercoiled causing twists that stress the molecule. This tension can be eased by (a) the formation of Okazaki fragments (b) the action of topoisomerase (c) the looping of the lagging strand (d) the action of DNA polymerase I (e) the action of DNA helicase

During DNA replication, as DNA unwinds it can become supercoiled causing twists that stress the molecule. This tension can be eased by (a) the formation of Okazaki fragments (b) the action of topoisomerase (c) the looping of the lagging strand (d) the action of DNA polymerase I (e) the action of DNA helicase

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 18QP: Replication involves a period of time during which DNA is particularly susceptible to the...

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Consider a DNA molecule with the following structure a. if during replication , the T at position 4 is read as an A resulting in a misincorporation in the new DNA strand . If the misincorporation is not repair , draw or write the results of the second round of replication b. After the second round of replication , what specific type of point mutation is now permanent in the DNA sequence ? c. List the two cellular mechanisms that failed to prevent the establishment of this permanent mutation .
Explain briefly how the double-helical structure of DNA suggests a mechanism for DNA replication?
Regarding the process of DNA replication, it is correct to state that: a) Nucleosomes are maintained during the DNA polymerase-mediated replication process b) The phosphodiester bonds that join the nitrogenous bases maintain the integrity of the DNA strands c) DNA polymerase requires a previously annealed deoxynucleotide to add the next monomer being synthesized. d) The action of the helicase decreases the twist caused by the movement of the replication complex along the stretch of DNA e)
How is the DNA unwound at the replication fork? What effect does this have on the DNA upstream of the fork, and how does the cell deal with this effect? b. Sliding clamps are topologically-closed rings that can encircle the DNA double helix. How, then, are they able to get on and off the DNA? What purpose is served by this striking topology?
During DNA replication, short RNA primers are made by the Primase. Why? a. To provide a 3'-OH so DNA polymerase can begin DNA synthesis. b. To recruit single stranded binding proteins to the correct location. c. To identify the termination sequence for DNA polymerase during DNA synthesis. d. To provide a 3'-OH so RNA polymerase can begin DNA synthesis. e. To identify the origin of replication to recruit the origin replication complex to the correct genomic location.
Suppose a future scientist explores a distant planet and discovers a novel form of double-stranded nucleic acid. When this nucleic acid is exposed to DNA polymerases from E. coli, replication takes place continuously on both strands. What conclusion can you draw about the structure of this novel nucleic acid?
a) If you isolated DNA from the ear and the tail of the same mouse, would you expect the DNA, isolated from the two tissue types, to be the same? Why? b) Provide one difference between DNA replication in eukaryotes and prokaryotes with regard to their origin (s) of replication.
It was once thought that the DNA polymerase machinery moves along DNA in a manner analogous to a train on a track. Current evidence indicates that the polymerizing machinery is instead stationary and that the DNA strands are pumped through the complex. What advantages does this stationary mechanism have?
What factors promote the fidelity of replication during the synthesis of the leading strand of DNA? Would you expect the lagging strand to be made with the same fidelity? Why or why not? Explain your answer briefly.
In terms of new DNA strands that are generated, what are the differences between replication and conventional polymerase chain reactions?
In terms of the new DNA strands that are generated, what are the differences between replication and conventional polymerase chain reaction?
DNA solution is viscous because of the nature of chemical substance that can intercalate into the DNA helix. An example of such substance is acridine orange. experiments revealed that acridine orange causes an increase in the viscosity of DNA solution.how would you account for this effect?