EXTEND YOUR UNDERSTANDING WITH ADDITIONAL TRC PROBLEMS Total fingerprint ridge count exemplifies a polygenic inheritance pattem. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active (dominant) allele adds 12 ridges to the TRC of the male and 9 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 80 for males and 70 for females. (one answer is given below to calify any issues with the instructions). 1. Predict the TRC for each of the following individuals. Genotype Male Female AABBCCDD AabbccDd answer = 104 AABBCCDD aaBbCCDd 11 Genetics 2. Write the genotypes of both parents (parental cross) who are heterozygous for all four genes (tetrahybrid cross). Write the genotype of the child (from the cross above in Question 2) who has the maximum number of active alleles possible. a. What are the TRCS for the parents and their child (assume that the child is a male)? Parents: Child:

EXTEND YOUR UNDERSTANDING WITH ADDITIONAL TRC PROBLEMS Total fingerprint ridge count exemplifies a polygenic inheritance pattem. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active (dominant) allele adds 12 ridges to the TRC of the male and 9 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 80 for males and 70 for females. (one answer is given below to calify any issues with the instructions). 1. Predict the TRC for each of the following individuals. Genotype Male Female AABBCCDD AabbccDd answer = 104 AABBCCDD aaBbCCDd 11 Genetics 2. Write the genotypes of both parents (parental cross) who are heterozygous for all four genes (tetrahybrid cross). Write the genotype of the child (from the cross above in Question 2) who has the maximum number of active alleles possible. a. What are the TRCS for the parents and their child (assume that the child is a male)? Parents: Child:

Name: 6. In solving problems 1-4, you made some predictions of TRCs based on
Uploaded: 2024-03-20T06:43:04.000Z
Channel: Bartleby
Description: 6. In solving problems 1-4, you made some predictions of TRCs based on the genotypesof the individuals involved. Suppose we could measure the TRCs for some people withthose genotypes and found the actual values to be different from those predicted by

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter5: The Inheritance Of Complex Traits

Section: Chapter Questions

Problem 22QP: Height in humans is controlled by the additive action of genes and the action of environmental...

See similar textbooks

Similar questions

Working with the definitions of penetrance and expressivity, analyze the following pedigree and assume that the father of the proband is homozygous for a rare trait. (Consider a rare trait here to be less than 1 in 30,000.) What pattern of inheritance other than autosomal recessive could explain this pedigree? In particular, explain the genotype and phenotype of the proband (arrow).
Total fingerprint ridge count exemplifies a polygenic inheritance pattern. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females. Predict the TRC for each of the following individuals: Genotype Male Female AABBCCDD AabbccDd AaBBCcDD aaBbCCDd A. Write the genotypes of parents who are heterozygous for all four genes. B. Write the genotype of their child who has the maximum number of active alleles possible. C. What are the TRCs for the parents? D. What is the TRC of the child from B (assume male)?…
Total fingerprint ridge count exemplifies a polygenic inheritance pattern. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females. Predict the TRC for each of the following individuals: Genotype Male Female AABBCCDD AabbccDd AaBBCcDD aaBbCCDd
. The production of pigment in the outer layer of seedsof corn requires each of the three independently assorting genes A, C, and R to be represented by at leastone dominant allele, as specified in Problem 64. Thedominant allele Pr of a fourth independently assortinggene is required to convert the biochemical precursorinto a purple pigment, and its recessive allele pr makesthe pigment red. Plants that do not produce pigmenthave yellow seeds. Consider a cross of a strain of genotype A/A ; C/C ; R/R ; pr/pr with a strain of genotypea/a ; c/c ; r/r ; Pr/Pr.a. What are the phenotypes of the parents?b. What will be the phenotype of the F1?c. What phenotypes, and in what proportions, willappear in the progeny of a selfed F1?d. What progeny proportions do you predict from thetestcross of an F1?
Mendel's concept of dominance states that in a genotype where two different alleles of a locus are present, only the trait encoded by the dominant allele is observed. Give a molecular explanation for dominance, i.e. explain intracellular molecular events that can result in what we observe as dominance on a phenotypic level. Use the gene that encodes seed shape in peas as an example, where roun(R) is dominant over wrinkled(r), to explain how RR and Rr plants can have the same phenotype.
More Crosses with Pea Plants: The Principle of Independent Assortment Determine the possible genotypes of the following parents by analyzing the phenotypes of their children. In this case, we will assume that brown eyes (B) is dominant to blue (b) and that right-handedness (R) is dominant to left-handedness (r). a. Parents: brown eyes, right-handed brown eyes, right-handed Offspring: 3/4 brown eyes, right-handed 1/4 blue eyes, right-handed b. Parents: brown eyes, right-handed blue eyes, right-handed Offspring: 6/16 blue eyes, right-handed 2/16 blue eyes, left-handed 6/16 brown eyes, right-handed 2/16 brown eyes, left-handed c. Parents: brown eyes, right-handed blue eyes, left-handed Offspring: 1/4 brown eyes, right-handed 1/4 brown eyes, left-handed 1/4 blue eyes, right-handed 1/4 blue eyes, left-handed
The ABO blood groups in humans are expressed as the IA,IB and i alleles. The IAallele encodes the A blood group antigen, IB encodes B, and i encodes O. Both A and B are dominant to 0. If a heterozygous blood type A parent (IAi) and a heterozygous blood type B parent (IBi) mate, one quarter of their offspring are expected to have the AB blood type IAIBin which both arnigens are expressed equally. Therefore, ABO blood groups are an example of: a. multiple alleles and incomplete dominance b. codominance and incomplete dominance c. incomplete dominance only d. multiple alleles and codominance
Height in humans is controlled by the additive action of genes and the action of environmental factors. For the purposes of this problem, assume that height is controlled by four genesA, B, C, and Dand that there are no environmental effects. Assume further that additive alleles contribute two units of height and partially additive alleles contribute one unit of height. a. Given these assumptions, can two individuals of moderate height produce offspring that are much taller and shorter than either parent? If so, how can this happen? b. Can someone of minimum height and someone of intermediate height have children taller than the parent of intermediate height? Why or why not?
INTERPRET DATA Using the graph in Figure 11-20, determine how many offspring were involved in the hypothetical cross studying skin color. What percentage had the lightest skin possible? the darkest skin possible? Figure 11-20 Polygenic inheritance in human s pigmentation This simplified example assumes that skin pigmentation in humans is governed by alleles of three unlinked loci. The alleles producing dark skin (A, B, and C) are represented by capital letters, but they are not dominant. Instead, their effects are additive. The number of dark dots, each signifying an allele producing dark skin, is counted to determine the phenotype. A wide range of phenotypes is possible when individuals of intermediate phenotype mate and have offspring (AaBbCc AaBbCc). The expected distribution of phenotypes is consistent with the superimposed normal distribution curve.
Crossing Pea Plants: Mendels Study of Single Traits An unspecified characteristic controlled by a single gene is examined in pea plants. Only two phenotypic states exist for this trait. One phenotypic state is completely dominant to the other. A heterozygous plant is self-crossed. What proportion of the progeny of plants exhibiting the dominant phenotype is homozygous?
This problem examines possible biochemical explanations for variations of Mendel’s 9:3:3:1 ratio. Exceptwhere indicated, compounds 1, 2, 3, and 4 have different colors, as do mixtures of these compounds. Aand B are enzymes that catalyze the indicated steps ofthe pathway. Alleles A and B specify functional enzymes A and B, respectively; these are completelydominant to alleles a and b, which do not specify anyof the corresponding enzyme. If functional enzyme ispresent, assume that the compound to the left of thearrow is converted completely to the compound to theright of the arrow. For each pathway, what phenotypicratios would you expect among the progeny of a dihybrid cross of the form Aa Bb × Aa Bb?a. Independent pathwaysCompound 4Compound 2Compound 3Compound 1Enz AEnz Bb. Redundant pathwaysCompound 1 Compound 2Enz BEnz Ac. Sequential pathwayCompound 1 Compound 2 Compound 3Enz A Enz Bd. Enzymes A and B both needed to catalyze the reaction indicated.Compound 1 Compound 2
The Online Mendelian Inheritancein Man (OMIM) databaseis a catalog of human genesand human disorders that are inheritedin a Mendelian manner. Genetic disordersthat arise from major chromosomalaberrations, such as monosomyor trisomy(the loss of a chromosome orthe presence of a superfluous chromosome,respectively), are not included.The OMIM database, updated daily, is aversion of the book Mendelian Inheritancein Man, conceived and edited by Dr. VictorMcKusick of Johns Hopkins University,until he passed in 2008.The OMIM entries provide links to awealth of information, including DNAand protein sequences, chromosomalmaps, disease descriptions, and relevantscientific publications. In this exercise,you will explore OMIM to answer questionsabout the recessive human diseasesickle-cell anemia and other Mendelianinherited disorders.Exercise I – Sickle-Cell AnemiaIn this chapter, you were introduced torecessive and dominant human traits.You will now discover more about sicklecellanemia as an…