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FasL (in a somatic cell ) interaction with Fas receptor in ( an immune cell) will lead to ............ of the immune cell.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 6QP

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FasL (in a somatic cell ) interaction with Fas receptor in ( an immune cell) will lead to ............ of the immune cell.

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The genetic content of each somatic cell in an organism is the same, but not all genes are expressed in every cell. Why can't cells express all the genes they have?
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T cells and B cells have many similarities in how they produce their highly diverse repertoire of antigen receptors, but one important difference between them is that B cell receptors can undergo somatic hypermutation to alter their affinity for antigen. This is known as ‘affinity maturation’, and the result is that the pool of B cells specific for a particular microbe will increase their binding affinity. T cells do not engage in either somatic hypermutation or affinity maturation. Why not? What potential harm could come from allowing T cells to alter the affinity of their TCRs after they have already left the thymus and have become activated in a lymph node or spleen?
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