Fill in the appropriate reagents to achieve the synthetic transformation shown below. Note: If one or more reagents are incorrectly placed, a single red X will appear on the top left. 1. он 2. 3. 4. 5. PCC, DCM Br(CH2)2CH3 benzylamine CH3(CH2)2MGB NABH3CN, cat. H*, cyclohexylamine acetone H3O* NaOH NazCr207, H20, H2SO4 cyclohexylbromide
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- Consider the following transformation below, which Prof. Ingoglia conducted during his post-doctoral research. a. Draw the product of the reaction in the box provided. b. Provide an arrow-pushing mechanism for the formation of the product you drew in part (a).1. Draw a reasonable arrow-pushing mechanism for the transformation shown along. 2. Identify nucleophiles and electrophiles 3. Name any type of reactions taking place like E2 or E1 4. Account for any regio- or stereoselectivityPlease show the mechanisms that convert compound 1 into compound 2. Thank you!
- Which is the better retrosynthesis for the given target molecule? Explain, and provide a one-step synthesis of the target molecule. A A is the better starting material because B can form both E and Z alkenes. B A is the better starting material because it will produce only the desired target molecule. C B is the better starting material because only B has β protons in the trans position. D B is the better starting material because A can form both E and Z alkenes. E B is the better starting material because it will produce only the desired target molecule. F A is the better starting material because only A has β protons in the trans position.This is Wittig Rxn: Whatever mechanism you choose to draw is fine since you can leave the base as B: Draw the arrow pushing mechanism using the compounds below – Constant: 4-nitrobenzyl benzaldehydebase 1: triethylaminebase 2: NaOHbase 3: K2CO3ylide: Acetonyltriphenylphosphonium chlorideWhen drawing organic chemistry mechanisms with NaOCH3, do we automatically dissociate it into Na+ and OCH3-, making it easier to go through SN2 and/or E2 reactions? Does NaOCH3 dissociate, and is this why it is a strong nucleophile?
- Chemistry Find the most efficient synthetic route for the followinf transformations.Draw the molecule: Under second-order conditions (strong base/nucleophile), SN2 and E2 reactions may occur simultaneously and compete with each other.Show what products might be expected from the reaction of 2-bromo-3-methylbutane (a moderately hindered 2∘∘ alkyl halide) with sodium ethoxide. Do not worry about sterechemistry inther SN2 product for this problem. Don't forget about stereochemistry.1. Which of the following is the strongest nucleophile? Refer to the diagram below with an MeOH, MeSH, etc. 2. Which of the following is true about the stereochemistry of SN1 reaction?a.retention of configuration at the electrophilic centerb.50:50 mixture of retention and inversion of configuration at the electrophilic centerc.inversion of configuration at the electrophilic centerd. slightly more inversion than retention at the electrophilic center
- Uridine monophosphate (UMP) is one of the four nucleotides that compose RNA, the nucleic acid that translates the genetic information of DNA into proteins needed by cells for proper function and development. A key step in the synthesis of UMP is the SN1 reaction of A with B to form C, which is then converted to UMP in one step. Draw a stepwise mechanism for this SN1 reaction.Provide a synthesis that results in the two products shown, starting from the given starting material. (Estimated number of steps = 5)Design an efficient synthesis of just one of the molecules below from the starting reagent shown and any other necessary reagents. A retrosynthetic analysis must be provided. No mechanism is needed.