Flies homozygous for recessive null mutations in thesevenless (sev) or bride-of-sevenless (boss) genes have the same mutant phenotype: Every ommatidium(facet) in their eyes lacks photoreceptor cell 7 (R7).The R7 cells enable flies to detect UV light.a. Given that flies normally move toward light, suggest a screening method that would enable you toidentify mutations in additional genes required forR7 determination.b. Would you be able to recover mutations in everygene required for R7 development with yourmethod? Explain.c. How could you tell whether any of the new mutationsyou found in your screen are alleles of sev or boss?d. Suppose you found one recessive mutant allele ofa gene not previously known to be involved in eyedevelopment. How could you use this allele in anew mutagenesis screen to find additional allelesof this gene? Why might you want additional mutant alleles to study the process?
Flies homozygous for recessive null mutations in the
sevenless (sev) or bride-of-sevenless (boss) genes have the same mutant
(facet) in their eyes lacks photoreceptor cell 7 (R7).
The R7 cells enable flies to detect UV light.
a. Given that flies normally move toward light, suggest a screening method that would enable you to
identify mutations in additional genes required for
R7 determination.
b. Would you be able to recover mutations in every
gene required for R7 development with your
method? Explain.
c. How could you tell whether any of the new mutations
you found in your screen are alleles of sev or boss?
d. Suppose you found one recessive mutant allele of
a gene not previously known to be involved in eye
development. How could you use this allele in a
new mutagenesis screen to find additional alleles
of this gene? Why might you want additional mutant alleles to study the process?
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