Question

Propose reagents and experimental conditions for the conversion of D to albuterol.

Following is a synthesis for albuterol (Proventil), currently one of the most widely used
inhalation bronchodilators.
CH,0
CH,
Но
CHO
Но-
-CHO
-СНО
NaOH
CH,S-CH,
DMSO, NaH
Но-
4-Hydroxybenzaldehyde
A
B
NH
NH
Но
OH
OH
Но
C
D
Albuterol
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Transcribed Image Text

Following is a synthesis for albuterol (Proventil), currently one of the most widely used inhalation bronchodilators. CH,0 CH, Но CHO Но- -CHO -СНО NaOH CH,S-CH, DMSO, NaH Но- 4-Hydroxybenzaldehyde A B NH NH Но OH OH Но C D Albuterol