Glucose | The three enzymes that catalyze reactions so highly exergonic as to be virtually irreversible (arrows) are I HK subject to allosteric control. G6P F6P IPFK FBP DHAP GAP |BPG=3PG=2PG GAP PEP Most of the reactions function at or near equilibrium and are freely PK reversible in vivo. Pyr Pathway progress A FIGURE 12.8 Energy profile of anaerobic glycolysis. The graph shows the change in actual free energy for each reaction in the pathway, based on estimated AG values calculated in Table 12.1. Metabolite and enzyme abbreviations are as defined in Table 12.1. Energy, AG

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 12P
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Refer to Figure, which indicates ∆G for each glycolytic reaction under intracellular conditions. Assume that glyceraldehyde-3-phosphate dehydrogenase was inhibited with iodoacetate, which reacts with its active site cysteine sulfhydryl group. Which glycolytic intermediate would you expect to accumulate most rapidly, and why?

Glucose
| The three enzymes that
catalyze reactions so highly
exergonic as to be virtually
irreversible (arrows) are
I HK subject to allosteric control.
G6P
F6P
IPFK
FBP
DHAP GAP
|BPG=3PG=2PG
GAP
PEP
Most of the reactions function at
or near equilibrium and are freely
PK
reversible in vivo.
Pyr
Pathway progress
A FIGURE 12.8 Energy profile of anaerobic glycolysis. The graph shows
the change in actual free energy for each reaction in the pathway, based
on estimated AG values calculated in Table 12.1. Metabolite and enzyme
abbreviations are as defined in Table 12.1.
Energy, AG
Transcribed Image Text:Glucose | The three enzymes that catalyze reactions so highly exergonic as to be virtually irreversible (arrows) are I HK subject to allosteric control. G6P F6P IPFK FBP DHAP GAP |BPG=3PG=2PG GAP PEP Most of the reactions function at or near equilibrium and are freely PK reversible in vivo. Pyr Pathway progress A FIGURE 12.8 Energy profile of anaerobic glycolysis. The graph shows the change in actual free energy for each reaction in the pathway, based on estimated AG values calculated in Table 12.1. Metabolite and enzyme abbreviations are as defined in Table 12.1. Energy, AG
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