Human geneticists have found the Finnish populationto be very useful for studies of a variety of conditions.The population is small; Finns have extensive churchrecords documenting lineages; and few people havemigrated into Finland. The frequency of some recessive disorders is higher in the Finnish population thanelsewhere in the world, and diseases such as PKU andcystic fibrosis that are common elsewhere do not occur in the Finnish population.a. How would a population geneticist explain thesevariations in disease occurrence?b. The Finnish population is also a source ofinformation for the study of quantitative traits. Thegenetic basis of schizophrenia is one question that canbe explored in this population. What advantage(s) anddisadvantage(s) can you imagine for studying complex traits based on the Finnish population structure?

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Author:Elaine N. Marieb, Katja N. Hoehn
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Human geneticists have found the Finnish population
to be very useful for studies of a variety of conditions.
The population is small; Finns have extensive church
records documenting lineages; and few people have
migrated into Finland. The frequency of some recessive disorders is higher in the Finnish population than
elsewhere in the world, and diseases such as PKU and
cystic fibrosis that are common elsewhere do not occur in the Finnish population.
a. How would a population geneticist explain these
variations in disease occurrence?
b. The Finnish population is also a source of
information for the study of quantitative traits. The
genetic basis of schizophrenia is one question that can
be explored in this population. What advantage(s) and
disadvantage(s) can you imagine for studying complex traits based on the Finnish population structure?

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