Question
Asked Oct 15, 2019
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If you assumed 2 genes were linked, what phenotypic ratio would you expect when crossing a female with 2 wild-type alleles and a male with 2 mutant alleles?

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Expert Answer

Step 1

Genetic linkage is explained as the closeness of genes on a chromosome (closely packed DNA molecule) that explains why two genes are inherited together in an individual.

Step 2

Homologous Chromosomes (pair of chromosomes that have similar, centromere location, gene position and length) exchanges their segments during the process of crossing over (occurs during meiosis) and generates recombinant chromosomes. The frequency of formation of recombinant chromosomes depend on the proximity of two genes on a chromosome. If two genes are very closely located, they will be exchanged together and thus defines that higher recombination frequency means that the two genes are not located in proximity.

Recombination frequency is always less than the parental frequency. Crossing over frequency is always less then 50% and parental genotypic frequency is always greater than 50%.

Step 3

In the give case, the two crossing individuals are homozygous for wild type and mutant alleles and since they are not assorting independently the recombination frequency between them depends on the closeness between...

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