
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Imagine protein X, destined to span the
plasma membrane. Assume that the mRNA carrying the genetic
message for protein X has already been translated by ribosomes
in a cell culture. If you fractionate the cells (see Figure 6.4), in
which fraction would you find protein X? Explain by describing
its transit through the cell.
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- What is unique about the translocation of ER proteins into the ER lumen vs. the translocation of proteins across other organelle membranes?arrow_forwardCargo proteins are transported through the Golgi apparatus to the trans-Golgi network, where they are sorted into various vesicles that are targeted to different destinations. What is the role of vesicles in -cargo protein transport through the Golgi apparatus?arrow_forwardDescribe the process of protein synthesis and trafficking of a protein, a lysosomal hydrolase, destined to be inside the lysosome. You do not need to detail the mechanism of translation but do state the role of the ribosome in getting your hydrolase to the lysosome. Include how the pulse-chase experiment could help demonstrate the path taken by the protein on its way to the lysosome. What is function and purpose of the organelles the protein will pass through and how it gets from organelle to organelle. In other words, what happens to the protein along the way?arrow_forward
- What characteristic of the plasma membrane allows for themovement of the G protein complex toward and away fromthe receptor protein?arrow_forwardPlease answer asap 15) Which molecular tag selects cargo proteins for lysosome. What molecular tag is required to retain/retrieve proteins in the RER?arrow_forwardWith reference to named examples, give a detailed account of the molecules and processes involved in trafficking soluble and membrane proteins from the Trans Golgi Network (TGN) to lysosomes. Include in your answer an explanation of how the trafficking machinery is recycled back, to the Trans Golgi Network in each case.arrow_forward
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