net free energy of coupled glucose breakdown and ATP synthesis be more or less favorable than the answer for net free energy of coupled glucose breakdown and ATP synthesis in organism in standard conditions. Please explain answer

net free energy of coupled glucose breakdown and ATP synthesis be more or less favorable than the answer for net free energy of coupled glucose breakdown and ATP synthesis in organism in standard conditions. Please explain answer

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter18: Glycolysis

Section: Chapter Questions

Problem 12P

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Question

Imagine that the concentrations of reactants and products for the coupled reactions above in the cell are at a level that yields a smaller molar ratio of the concentrations than those relevant to the standard state conditions. Would the net free energy of coupled glucose breakdown and ATP synthesis be more or less favorable than the answer for net free energy of coupled glucose breakdown and ATP synthesis in organism in standard conditions. Please explain answer

imagine an organism that produces lactate as the only product of glucose
metabolism
glucose
2 lactate
The Gibbs free energy change for this reaction is AG'o=-47 kcal/mol
The breakdown of 1 mol of glucose produces 2 moles of ATP
2P; + 2 ADP
2 ATP
and the standard Gibbs free energy of ATP synthesis is AGo=7.3 kcal/mol

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