In 1952, an article in the British Medical Journalreported interesting differences in the behavior ofblood plasma obtained from several people who suffered from X-linked recessive hemophilia. Whenmixed together, the cell-free blood plasma from certain combinations of individuals could form clots inthe test tube. For example, the following table showswhether clots could form (+) or not (−) in variouscombinations of plasma from four people withhemophilia:1 and 1 − 2 and 3 +1 and 2 − 2 and 4 +1 and 3 + 3 and 3 −1 and 4 + 3 and 4 −2 and 2 − 4 and 4 −What do these data tell you about the inheritance ofhemophilia in these individuals? Do these data allowyou to exclude any models for the biochemical pathway governing blood clotting?
In 1952, an article in the British Medical Journal
reported interesting differences in the behavior of
blood plasma obtained from several people who suffered from X-linked recessive hemophilia. When
mixed together, the cell-free blood plasma from certain combinations of individuals could form clots in
the test tube. For example, the following table shows
whether clots could form (+) or not (−) in various
combinations of plasma from four people with
hemophilia:
1 and 1 − 2 and 3 +
1 and 2 − 2 and 4 +
1 and 3 + 3 and 3 −
1 and 4 + 3 and 4 −
2 and 2 − 4 and 4 −
What do these data tell you about the inheritance of
hemophilia in these individuals? Do these data allow
you to exclude any models for the biochemical pathway governing blood clotting?
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