) In Drosophila, crosses between F1 heterozygotes of the form A b/a B always yield the same ratio of phenotypes in the F2 progeny regardless of the distance between the two genes (assuming complete dominance for both autosomal genes). What is this ratio? Would this also be the case if the F1 heterozygotes were A B/a b? (Hint: Remember that in Drosophila, recombination does not take place during spermatogenesis.)

Question
  1. a) In Drosophila, crosses between F1 heterozygotes of the form A b/a B always yield the same ratio of phenotypes in the F2 progeny regardless of the distance between the two genes (assuming complete dominance for both autosomal genes). What is this ratio? Would this also be the case if the F1 heterozygotes were A B/a b? (Hint: Remember that in Drosophila, recombination does not take place during spermatogenesis.)

 

  1. b) If you intercrossed F1 heterozygotes of the form A b/a B in mice, the phenotypic ratio among the F2 progeny would vary with the map distance between the two genes. Is there a simple way to estimate the map distance based on the frequencies of the F2 phenotypes, assuming rates of recombination are equal in males and females? Could you estimate map distances in the same way if the mouse F1 heterozygotes were A B/a b?

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