мь 7G YA 200- a chalns p chalns 400- Primordlal myoglobin Primordial hemoglobin 600- FIGURE 8.7 The evolution of the globin gene family in humans. The globin gene family evolved from a single ancestral globin gene. The first gene duplication produced two genes, one that encodes myoglobin (on chromosome 22) and a primordial hemoglobin gene that duplicated several times to produce several a-chain and -chain genes, which are found on chromosomes 16 and 11, respectively. The four genes shown in gray are nonfunctional pseudogenes. 800- Ancestral globin 1000 Milions of years ago

мь 7G YA 200- a chalns p chalns 400- Primordlal myoglobin Primordial hemoglobin 600- FIGURE 8.7 The evolution of the globin gene family in humans. The globin gene family evolved from a single ancestral globin gene. The first gene duplication produced two genes, one that encodes myoglobin (on chromosome 22) and a primordial hemoglobin gene that duplicated several times to produce several a-chain and -chain genes, which are found on chromosomes 16 and 11, respectively. The four genes shown in gray are nonfunctional pseudogenes. 800- Ancestral globin 1000 Milions of years ago

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 15QP

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Researchers in search of loci in the human genome that arelikely to contribute to the constellation of factors leading tohypertension have compared candidate loci in humans and rats[Stoll, M., et al. (2000). New Target Regions for Human Hypertensionvia Comparative Genomics. Genome Res. 10:473–482].Through this research, they identified 26 chromosomal regionsthat they consider likely to contain hypertension genes. Howcan comparative genomics aid in the identification of genesresponsible for such a complex human disease? The researchersstate that comparisons of rat and human candidate loci tothose in the mouse may help validate their studies. Why mightthis be so?
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