Many antibiotics are effective as drugs to fight off bacterial infections because they inhibit protein synthesis in bacterial cells. Using the information provided in the following table that highlights several antibiotics and their mode of action, discuss which phase of translation is inhibited: initiation, elongation, or termination. What other components of the translational machinery could be targeted to inhibit bacterial protein synthesis? Antibiotic Action 1. Streptomycin Binds to 30S ribosomal subunit 2. Chloramphenicol Inhibits peptidyl transferase of 70S ribosome 3. Tetracycline Inhibits binding of charged tRNA to the A site of the ribosome 4. Erythromycin Binds to free 50S particle and prevents formation of 70S ribosome 5. Kasugamycin Inhibits binding of tRNAfMet 6. Thiostrepton Prevents translocation by inhibiting EF-G
Bacterial Genomics
The study of the morphological, physiological, and evolutionary aspects of the bacterial genome is referred to as bacterial genomics. This subdisciplinary field aids in understanding how genes are assembled into genomes. Further, bacterial or microbial genomics has helped researchers in understanding the pathogenicity of bacteria and other microbes.
Transformation Experiment in Bacteria
In the discovery of genetic material, the experiment conducted by Frederick Griffith on Streptococcus pneumonia proved to be a stepping stone.
Plasmids and Vectors
The DNA molecule that exists in a circular shape and is smaller in size which is capable of its replication is called Plasmids. In other words, it is called extra-chromosomal plasmid DNA. Vectors are the molecule which is capable of carrying genetic material which can be transferred into another cell and further carry out replication and expression. Plasmids can act as vectors.
Many antibiotics are effective as drugs to fight off bacterial infections
because they inhibit protein synthesis in bacterial cells.
Using the information provided in the following table that highlights
several antibiotics and their mode of action, discuss which
phase of translation is inhibited: initiation, elongation, or termination.
What other components of the translational machinery
could be targeted to inhibit bacterial protein synthesis?
Antibiotic Action
1. Streptomycin Binds to 30S ribosomal subunit
2. Chloramphenicol Inhibits peptidyl transferase of
70S ribosome
3. Tetracycline Inhibits binding of charged tRNA to
the A site of the ribosome
4. Erythromycin Binds to free 50S particle and prevents
formation of 70S ribosome
5. Kasugamycin Inhibits binding of tRNAfMet
6. Thiostrepton Prevents translocation by
inhibiting EF-G
Trending now
This is a popular solution!
Step by step
Solved in 5 steps
