Many genes in both bacteria and eukaryotes contain numerous sequences that can cause pauses in or premature termination of transcription. Nevertheless, the transcription of these genes within a cell normally produces multiple RNA molecules thousands of nucleotides long without pausing or premature termination. However, when a single round of transcription of these genes takes place in a test tube, RNA synthesis is frequently interrupted by pauses and premature terminations, which reduce the rate at which transcription takes place and frequently shorten the lengths of the mRNA molecules produced. Most pauses and premature terminations occur when RNA polymerase temporarily backtracks (i.e., backs up) for one or two nucleotides along the DNA. Experimental findings have demonstrated that most pauses and premature terminations disappear if several RNA polymerases are simultaneously transcribing the DNA molecule. Propose an explanation for this observation of faster transcription and longer mRNAs when the template DNA is being transcribed by multiple RNA polymerases.

Question

Many genes in both bacteria and eukaryotes contain numerous
sequences that can cause pauses in or premature termination of
transcription. Nevertheless, the transcription of these genes within a cell
normally produces multiple RNA molecules thousands of nucleotides
long without pausing or premature termination. However, when a single
round of transcription of these genes takes place in a test tube, RNA
synthesis is frequently interrupted by pauses and premature
terminations, which reduce the rate at which transcription takes place
and frequently shorten the lengths of the mRNA molecules produced.
Most pauses and premature terminations occur when RNA polymerase
temporarily backtracks (i.e., backs up) for one or two nucleotides along
the DNA. Experimental findings have demonstrated that most pauses
and premature terminations disappear if several RNA polymerases are
simultaneously transcribing the DNA molecule. Propose an explanation
for this observation of faster transcription and longer mRNAs when the
template DNA is being transcribed by multiple RNA polymerases.

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