Many oncogenes result from mutations that cause excessive expression of a protein in cells where it is normally not expressed or is expressed at inappropriate times during development. This type of mutation can be described as ________. A) amorphic B) hypomorphic C)hypermorphic D) neomorphic E) dominant negative

Q: What are the chances of occurrence of hypermorphic mutation?

A: Mutations are defined as the permanent change in the DNA’s base sequence. The mutation that…

Q: What is PID? What causes it?

A: It consists of primary sex organs called gonads which produce gametes and hormones, secondary sex…

Q: What is the proper route for gene delivery in different kinds of disorders?

A: Gene therapy is a promising method for correcting host pathology by the manipulation of DNA…

Q: What is genomic reduction?

A: The genome size (C-value) is defined as the amount of deoxyribonucleic acid (DNA) in a haploid…

Q: An individual has the following sequences on his chromosomes at one locus:…

A: * Microsatellite sequences also called as short tandem repeats (STR) are repetitive DNA sequences…

Q: What causes the majority of the mutations found in human melanomas and lung cancer?

A: DNA is the chemical in each cells that makes up the genes and some genes control when cells grow,…

Q: What are Extranuclear genes?

A: Genetics is a branch of biology that deals with genes, heredity, and variation. Heredity purely…

Q: What is the difference between a germline mutation and a somatic mutation?

A: A mutation is a biological process occurring in the Deoxyribonucleic acid (DNA) sequence due to…

Q: What is Xenotransplantation ?

A: When organs or tissues are damaged or diseased, they may require repair or replacement. This purpose…

Q: is the p53 protein an activator or a repressor? How do you know?

A: p53 protein is protein which is coded by Tp53 gene which is also known by the name Gaurdian of the…

Q: What role Proto-oncogenes play ?

A: Deoxyribonucleic acid (DNA) is the instruction manual for the building of life. The complete set of…

Q: Why is cytokinesis important during the embryonic development?

A: A series of events that occurs in a cell to make it ready for the division is the cell cycle.  There…

Q: Why is fragile X, but not Huntington disease, considered a syndrome?

A: Fragile X syndrome causes various symptoms including developmental delays, cognitive impairment, and…

Q: How would a human with a mutation in a maternaleffect gene most likely be recognized?

A: Maternal genes are the genes that allow the deposition of their gene product like RNA or protein in…

Q: What is A hypermorphic mutation?

A: The mutations are classified based on their behavior in terms of genetic interactions. The Nobel…

Q: What type of epigenetic change is responsible for genomic imprinting?

A: Epigenetic refers to the patterns of inheritance that involve the alterations in characteristics…

Q: What is the difference between a lesion and an ablation?

A: Cells are the structural and fundamental units of life. Cells that possess similarity in structure…

Q: What is the function of a proto-oncogene?

A: Gene is the basic functional and structural unit of heredity. These are formed of DNA. Some genes…

Q: Why Recessive CF disease alleles either produce no CFTR or produce nonfunctional or less functional…

A: Cystic fibrosis (CF) is a classical example of recessive disease. It is a disease that is inherited.

Q: What protein does the P53 code for and why is it important?

A: Answer :- The TP53 quality gives guidelines to making a protein called growth protein p53 (or p53).…

Q: How will this mutation affect the golden retriever puppy?

A: Transcription is the process which makes mRNA from DNA in complementary manner. The A, U, G and C of…

Q: According to the multi-hit model, more than one mutation must occur in a cell for cancer to develop.…

A: A new multihit model of carcinogenesis is produced for use in assessing age-explicit disease rate…

Q: What is the last name of the scientist who discovered that x-rays can increase the rate of mutation…

A: The fruit flies in this exhibit represent only a small percentage of the mutations found in real…

Q: Which is the biological molecule that contains the genetic information that is transmitted…

A: The genome of an organism is defined as the whole genetic information that is inherited from one…

Q: Describe the changes that can convert a proto-oncogene into an oncogene.

A: A normal functioning gene turns into a proto-oncogene, which can cause cancer when it is altered as…

Q: why  CNVs are highly polymorphic ?

A: In humans two-third of the entire genome is made of copy number variants. These copy number variants…

Q: Why don’t all loss-of-function mutations that are recessive at the cellular level behave as…

A: Loss of function mutation refers to the mutation in a gene that leads to reduced or no function of…

Q: What type of epigenetic mark is responsible for genomic imprinting?

A: Epigenetic mark allows genes to switch off or on. These generally change the way genes are…

Q: What are knockout mutations?

A: Deoxyribonucleic acid or DNA is a molecule that contains the genetic code of the organisms. DNA…

Q: What are lethal genes?

A: Genes are the functional unit of life. They are accountable for the passing of the characters from…

Q: majority of cancers in human are due to mutations in the p53 gene, however, cancers that are caused…

A: P 53 protein is also known as the tumor suppressor protein which is a type of phosphoprotein edit…

Q: What types of functions are performed by the products of proto-oncogenes?

A: Small segments of DNA encodes information for different functions and structure of the cell and thus…

Q: When BRCA1 is absent, is it unable to transcribe genes like p21, which leads to senescence ?

A: Introduction Senescence is defined as the stage when the cell stops dividing permanently but does…

Q: Mutations must occur in which cells of the parent to be inherited by their offspring?

A: The cell is the essential underlying, utilitarian, and natural unit of every single known living…

Q: What is a multisubunit protein?

A: The cells are the basic building blocks of the living system. It consists of many internal…

Q: What is the significance of the Philadelphia chromosome, and how is it related to leukemia?

A: Chromosomes are the structures present in the nucleus that appear thread like and contain genes.…

Q: What is a A germline mutation?

A: A germinal mutation or germline mutation as the word indicates itself it is a mutation in germline…

Q: When  germ-line mutations occur ?

A: The alternation in the genome nucleotide sequence of an organism is called a mutation. These are due…

Q: What is the main lincRNA involved in X-inactivation, and what is known about its function?

A: Chromosomes are long thread-like structures that carry coded genetic information in the form of DNA.…

Q: How might overexpression of proto-oncogenes lead to abnormal cellular proliferation?

A: A proto-oncogene is a cell's normal gene. Proto-oncogenes are plentiful. Each one is in charge of…

Q: Explain maternal-effect mutations?

A: Mutation means sudden changes occur in DNA sequences. The mutation occurs randomly. It also occurs…

Q: Why does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a…

A: Proto- oncogene Activation of a proto- oncogene into an oncogene usually includes gain of function…

Q: In humans, why is it that the mother transmits nearly all of the extranuclear genes to her children?

A: A gene is the structural and functional unit of heredity. Genes are made of Deoxy ribonucleic acid…

Q: When Replacement of the original gene occurs ?

A: A gene is the essential physical and functional unit of heredity. They are comprised of DNA…

Q: What are three similarities and three differences between Germline mutations and Somatic mutations?

A: A mutation refers to the alteration in the sequence of DNA (deoxyribonucleic acid). It can be a…

Q: What is the experimental evidence that demonstrates direct evidence that chemical carcinogens are…

A: Introduction: carcinogen, any of the many substances that can give humans cancer. They fall into…

Q: How can the retinoblastoma trait be inherited in a dominant fashion if the deletion of the RB gene…

A: Retinoblastoma is an eye cancer that begins in the retina.

Q: What is retrograde?

A: Introduction  The proteins which are formed by the ribosomes attached over the ER are transported to…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.