Mapping quantitative trait loci (QTL) through lab crosses is one way to find the genetic variants responsible for variation in a trait. What is the rationale for why this approach works?

Essentials Of Human Development
1st Edition
ISBN:9781285647357
Author:Kail
Publisher:Kail
Chapter4: The Emergence Of Thought And Language: Cognitive Development In Infancy And Early Childhood
Section4.4: Language
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Studies on the possible adaptive value of anticipatory grief have produced results contrary to expectations: people that show more grief before the death of a loved one with a terminal disease also show more grief afterwards. What is a possible explanation for these findings?

  1. Grief is actually not adaptative – it’s just a side effect of our big brain
  2. Many other factors influence levels of grief and sadness (gender, past experiences, personality, age) which may obscure any underlying relationship
  3. The measurements of grief used in this study were too coarse, some quantitative measurement would be better than three qualitative categories
  4. All of the above

Mapping quantitative trait loci (QTL) through lab crosses is one way to find the genetic variants responsible for variation in a trait. What is the rationale for why this approach works?

  1. By systematically inhibiting the action of each gene, you can determine which genes affect which traits
  2. By sequencing the entire genome, you can determine which genes differ between populations, lines or species that vary in the trait of interest
  3. By shuffling the genomes of two genotypes you wish to contrast, you can figure out which regions (and genes within) are causally tied to the trait of interest
  4. By created controlled lines in common garden conditions, you can isolate the contribution of genetic variation versus environmental variation
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