Answered: Mechanism Friedel-Crafts acylation of…

Mechanism Friedel-Crafts acylation of anisole with acetic anhydride OCH3 CH3+CH3 C OH CH a Pathway-Formation of Ayliam lon 2d Pathway Anisole attacks entire Lewis Acid/Lewis Base Complex

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 35MP

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Question

What is the mechanism for the Friedel-Crafts Acylation of anisole and acetic anhydride?

Mechanism
Friedel-Crafts acylation of anisole with acetic anhydride
OCH3
CH3+CH3 C OH
CH a
Pathway-Formation of Ayliam lon
2d Pathway Anisole attacks entire Lewis Acid/Lewis Base Complex

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