он но Он OOH но Он unstable intermediate PGG2 PGF2a

Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter20: Enzymes
Section: Chapter Questions
Problem 20.2E: List two ways that enzyme catalysis of a reaction is superior to normal conditions.
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PGF2α (Section 4.15) is synthesized in cells from arachidonic acid (C20H32O2) using a cyclooxygenase enzyme that catalyzes a multistep radical pathway. Part of this process involves the conversion of radical A to PGG2, an unstable
intermediate, which is then transformed to PGF2α and other prostaglandins. Draw a stepwise mechanism for the conversion of A to PGG2. (Hint: The mechanism begins with radical addition to a carbon–carbon double bond to form a resonance-stabilized radical.)

он
но
Он
OOH
но
Он
unstable intermediate
PGG2
PGF2a
Transcribed Image Text:он но Он OOH но Он unstable intermediate PGG2 PGF2a
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