Page> of 6ZOOM +TCA cycle, oxidative phosphorylation, metabolic regulationTCA cycle (Ch. 16)1. The citric acid cycle has eight enzymes: citrate synthase, aconitase, isocitrate dehydrogenase,a-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase,and malate dehydrogenase.(a) Write a balanced equation for the reaction catalyzed by each enzyme.(b) Name the cofactor(s) required by each enzyme reaction.(c) For each enzyme determine which of the following describes the type of reaction(s)catalyzed: condensation (carbon–carbon bond formation); dehydration (loss of water); hydration(addition of water); decarboxylation (loss of CO2); oxidation-reduction; substrate-levelphosphorylation; isomerization.(d) Write a balanced net equation for the catabolism of acetyl-CoA to CO2.

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Asked Feb 21, 2020
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TCA cycle, oxidative phosphorylation, metabolic regulation
TCA cycle (Ch. 16)
1. The citric acid cycle has eight enzymes: citrate synthase, aconitase, isocitrate dehydrogenase,
a-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase,
and malate dehydrogenase.
(a) Write a balanced equation for the reaction catalyzed by each enzyme.
(b) Name the cofactor(s) required by each enzyme reaction.
(c) For each enzyme determine which of the following describes the type of reaction(s)
catalyzed: condensation (carbon–carbon bond formation); dehydration (loss of water); hydration
(addition of water); decarboxylation (loss of CO2); oxidation-reduction; substrate-level
phosphorylation; isomerization.
(d) Write a balanced net equation for the catabolism of acetyl-CoA to CO2.
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Page > of 6 ZOOM + TCA cycle, oxidative phosphorylation, metabolic regulation TCA cycle (Ch. 16) 1. The citric acid cycle has eight enzymes: citrate synthase, aconitase, isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase. (a) Write a balanced equation for the reaction catalyzed by each enzyme. (b) Name the cofactor(s) required by each enzyme reaction. (c) For each enzyme determine which of the following describes the type of reaction(s) catalyzed: condensation (carbon–carbon bond formation); dehydration (loss of water); hydration (addition of water); decarboxylation (loss of CO2); oxidation-reduction; substrate-level phosphorylation; isomerization. (d) Write a balanced net equation for the catabolism of acetyl-CoA to CO2.

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Expert Answer

Step 1

Hello. Since your question has multiple sub-parts, we will solve first three sub-parts for you. If you want remaining sub-parts to be solved, then please resubmit the whole question and specify those sub-parts you want us to solve.

Step 2

The tricarboxylic acid cycle carries out the oxidation of acetyl-CoA molecule that is produced by pyruvate oxidation. It involves a series of reactions that regenerate oxaloacetate molecule that takes part in the first condensation step of the cycle.

Biology homework question answer, step 2, image 1

Step 3
  • A cofactor is required for an enzyme to function appropriately. It is a metal ion or complex organic compound known as coenzymes.
  • The first irreversible condensation step catalyzed by citrate synthase requires coenzyme A. The second reaction catalyzed by aconitase requires iron-sulfur centers to carry out the migration of hydroxyl group for the synthesis of isocitrate. The third step catalyzed by isocitrate dehydrogenase requires nicotinamide adenine dinucleotide (NAD+). The fourth step is catalyzed by α-ketoglutarate dehydrogenase that requires five different cofactors. T...

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