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- What are two major functions of ATP hydrolysis in skeletal muscleactivity?Explain how the process of skeletal muscle excitation–contraction coupling demonstrates the general principle of physiology that controlled exchange of materials occurs between compartments and across cellular membranes.The filaments of skeletal muscle are moved by free energy derived from the hydrolysis of ATP. During sustained muscle contraction ATP levels remain fairly constant, while levels of creatine phosphate fall. Explain why this is so. Under what circumstances is an oxygen debt incurred during muscle contraction?
- Outline the molecular mechanism for skeletal muscle contraction. At what point is ATP used and why?In human resting muscle cells, the concentration of ATP is 4 mM, ADP is 0.013 mM, creatine-phosphate is 25 mM and creatine is 13 mM. Calculate the ΔG for the formation of creatine phosphate from ATP and creatine in kJ/mol and do not include unit in your answer.Briefly describe why contraction of the muscle cell is called “sliding filament theory” (what is sliding?) and what do we mean by “excitation-contraction coupling?” (What is being excited, and what is coupled?)
- The sliding-filament model of skeletal-muscle contraction assumes a sliding or slipping of interdigitating filaments of actin and myosin. Electron micrographs show that during contraction the actin and my-osin filaments remain of constant length while the distance between Z lines shortens. Explain how this happens in terms of the molecular structure of the muscle filaments. What is the role of regulatory pro-teins (troponin and tropomyosin) in contraction?Using the tension graph, explain why skeletal muscle can exhibit tetany (sustained contraction) but cardiac muscle cannot.During one cross-bridging cycle in striated muscle one ATP molecule is hydrolyzed. Explain the two times when the energy from this hydrolysis is used, and what “work” is done in each case.
- Explain the intracellular mechansim of smooth muscle relaxation of agaonist such as mepyrimine and atropine. Give diagram for each.The 2 main proteins in muscle cells are _______ and ___What structures/s is/are responsible for the banding pattern in skeletal muscle cells? (EXPLAIN) Explain the sliding filament theory of contraction. NO COPYPASTE FROM THE INTERNET, PLEASE! I ALREADY WASTED MY QUESTIONS TO SOME VERY SHORT and COPY-PASTED ANSWERS.