1Provide the reagent(s) (in the correct order) for the following:???H2N.OCH3OCH3Br`NO22.*y Provide the product and a stepwise mechanism for the followingnucleophilic aromatic substitution reaction. Include all intermediates, resonancestructures, and electron pushing arrows. If you need to redraw the structure toshow electron flow please do so.OHC,CH3NH2CI

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Provide the reagent(s) (in the correct order) for the following: ??? H2N. OCH3 OCH3 Br `NO2

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter18: Functional Derivatives Of Carboxylic Acids

Section: Chapter Questions

Problem 18.38P: A step in a synthesis of PGE1 (prostaglandin E1, alprostadil) is the reaction of a trisubstituted...

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Designing a Synthesis

Organic synthesis is a branch of chemical synthesis that involves the planned construction of organic compounds/molecules from smaller units that possess functional groups. Friedrich Wöhler was the first scientist who designed the synthesis of an organic compound, urea from inorganic starting materials silver cyanate with ammonium chloride via a simple, one-step synthesis.

Question

1
Provide the reagent(s) (in the correct order) for the following:
???
H2N.
OCH3
OCH3
Br
`NO2
2.
*y Provide the product and a stepwise mechanism for the following
nucleophilic aromatic substitution reaction. Include all intermediates, resonance
structures, and electron pushing arrows. If you need to redraw the structure to
show electron flow please do so.
OHC,
CH3NH2
CI

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