Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.

Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.

Chemistry: Principles and Reactions

8th Edition

ISBN:9781305079373

Author:William L. Masterton, Cecile N. Hurley

Publisher:William L. Masterton, Cecile N. Hurley

Chapter11: Rate Of Reaction

Section: Chapter Questions

Problem 87QAP: A drug decomposes in the blood by a first-order process. A pill containing 0.500 g of the active...

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