SR proteins are essential to proper spliceosome assembly and are known to take part in the regulation of alternative splicing. Surprisingly, the role of SR proteins in splice-site selection and alternative splicing is affected by the promoter used for the transcription of the pre-mRNA. For example, through genetic engineering, RNA polymerase II promoters that have somewhat different sequences can be created. When pre-mRNAs with exactly the same sequences are transcribed from two different RNA polymerase II promoters that differ slightly in sequence, which promoter is used can affect how the pre-mRNA is spliced. Propose a mechanism by which the DNA sequence of an RNA polymerase II promoter could affect alternative splicing of pre-mRNA.

Question

SR proteins are essential to proper spliceosome assembly and are known
to take part in the regulation of alternative splicing. Surprisingly, the
role of SR proteins in splice-site selection and alternative splicing is
affected by the promoter used for the transcription of the pre-mRNA.
For example, through genetic engineering, RNA polymerase II
promoters that have somewhat different sequences can be created. When
pre-mRNAs with exactly the same sequences are transcribed from two
different RNA polymerase II promoters that differ slightly in sequence,
which promoter is used can affect how the pre-mRNA is spliced.
Propose a mechanism by which the DNA sequence of an RNA
polymerase II promoter could affect alternative splicing of pre-mRNA.

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