The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph Ph ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN NaOEt KCN 1. NaOH, H2O Ph-CHO 2. HCI, Н-О 3. Нeat COOEt COOEt NC COOET Ethyl cyanoacetate (A) (B) Benzaldehyde Ph Ph Ph CH;NH2 HOOC COOH EtOOC COOEt (C) (D) CH3 Phensuximide In the conversion of (B) to (C), draw the structure of the product of step 1.
The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph Ph ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN NaOEt KCN 1. NaOH, H2O Ph-CHO 2. HCI, Н-О 3. Нeat COOEt COOEt NC COOET Ethyl cyanoacetate (A) (B) Benzaldehyde Ph Ph Ph CH;NH2 HOOC COOH EtOOC COOEt (C) (D) CH3 Phensuximide In the conversion of (B) to (C), draw the structure of the product of step 1.
Chapter27: Biomolecules: Lipids
Section27.SE: Something Extra
Problem 44AP
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