Question
Asked Oct 21, 2019
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How is this question begun?  How is the HH equation used?

The pKa of the a-carboxyl group of methionine is 2.28, and the pKa of its a-amino group is 9.21. Calculate the average net
charge on methionine if it is in a solution that has a pH of 8.50
average net charge on methionine:
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The pKa of the a-carboxyl group of methionine is 2.28, and the pKa of its a-amino group is 9.21. Calculate the average net charge on methionine if it is in a solution that has a pH of 8.50 average net charge on methionine:

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Expert Answer

Step 1

The Henderson-Hasselbalch equation is as follows

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1-a

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Step 2

On reaaranging the equation, we get the following equation

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1 а 3 10PК, apH +1

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Step 3

Now when we calculate the charge on methionine...

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ΣοΣο 1 10Pa1pH +1 10P2-pH 1 1 1 8.50-9.21 +1 102.88-9.21 1 1 11022 1+10-0.71

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