Answered: The proline isomerase activity of FK506…

The proline isomerase activity of FK506 is central to its mechanism of action as an inhibitor of the immune system response. * True * False

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 11QP: It is often helpful to draw a complicated pathway in the form of a flow chart to visualize the...

See similar textbooks

Related questions

Q: Which of the following enzymes plays a role in controlling the the half-life of cGMP? (Hint: It is…

A: cGMP or cyclic GMP is cyclization product of GTP by an enzyme called Guanylyl cyclase. This enzyme…

Q: involved clot formation and initiates wound healing through fibroblast stimulation? A. GPCR B.…

A: Hi, Thanks For Your Question. Answer : Correct Option Is D (PDGF) Explanation : Wound Healing Is A…

Q: Match if the following is CYP inducer or inhibitor Choices: 1. Ketaconazole Inducer 2.…

Q: Ivermectin is being vaunted as a cure for covid-19. Is it a primary or secondary metabolite? Discuss…

A: Ivermectin is an antihelmintics drugs used for the treatment of covid 19 patient. It kills parasites…

Q: Explain using 2-3 sentences the biological significance of the following peptides . Glucagon…

A: Peptides are short chains of amino acids linked by peptide bonds. Peptides are smaller than…

Q: CK1-41 is a non-competitive inhibitor of caspase-1. Explain.

A: Caspases are those proteases which have cysteine protease catalytic triad nucleophile activity and…

Q: BIM-46187 is a protein inhibitor that binds to the a-subunit of the Ga protein. It prevents the…

A: G protein coupled receptor mediated signalling is initiated upon binding of ligand that triggers a…

Q: Which patch clamp technique should be used if you want to investigate the effect a compound has…

A: The patch clamp technique - a laboratory technique. patch clamp technique used in electrophysiology…

Q: . Which of the following statements is TRUE regarding the effect of drug candidate X…

A: Introduction: Phosphofructokinase catalyzes the conversion of fructose 6-phosphate to fructose…

Q: Which of the following protein domains would you expect to find in an "easily druggable" target b…

A: * protein domain is a part of protein sequence and tertiary structure that can function and evolve…

Q: HbA1c is used to monitor blood glucose levels because hemoglobin is the only protein in blood that…

A: “Since you have asked multiple question, we will solve the first question for you. If youwant any…

Q: Activation of phosphatidylinositol-3-kinase (PI3K) stimulate protein-protein interactions. True…

A: PI3K or phosphatidylinositol-3Kinase is a protein, which involves the family of an enzyme that…

Q: Which ONE of these statements is the most accurate definition of the mode of action of imatinib?…

A: Chromosomal deletion is simply deletion of the part of the chromosome. Chromosomal inversion is a…

Q: Iodine-131 is commonly used for the treatment of Graves' disease, which is a disease of the thyroid…

A: Grave disease --It is an autoimmune condition where immune system of body affect the thyroid gland…

Q: HDL-R: HDLS carry cholesterol to the liver for elimination. Liver cells respond to estrogen to…

A: ER binds to specific DNA sequences called estrogen response elements (EREs) with high affinity and…

Q: HDL-R: HDLS carry cholesterol to the liver for elimination. Liver cells respond to estrogen to…

A: Answer :- Option (D) is correct. - Only the liver cell retains the HDL-R gene , the immune cell has…

Q: An amount of 20 uCi of 32p (TR 14.3 d) is injected into the bloodstream of a reference adult ( m =70…

A: Effective half life means the time taken for a given amount of a particular radionuclide present in…

Q: Estimate the binding affi nity of a ligand for its receptor from the followingdata:

A: The receptor is a protein that is found on the cell surface. These receptors bind to the ligand with…

Q: Di-isopropyl fluorophosphate is a(n) .................. inhibitor of chymotrypsin ? a) allosteric…

A: Chymotrypsin is a serine protease as contains a reactive serine in its active site. The active site…

Q: 1. α-ketoglutaric acid participates in the processes of transdeamination and transreamination of…

A: We’ll answer the first question since the exact one wasn’t specified. Please submit a new question…

Q: f a commercially available insulin preparation contains 1 ppm of proinsulin, how many micrograms of…

A: Glucose is a carbohydrate, which provides instant energy to the body for carrying out the various…

Q: HDL-R: HDLS carry cholesterol to the liver for elimination. Liver cells respond to estrogen to…

A: The principle behind microarrays is that complementary sequences will bind to each other.

Q: Hemophilia B, an X-linked genetic disorder which highly affects males, is a condition in which…

A: Hemophilia A and hemophilia B are X linked recessive genetic disorder which generally affects male.…

Q: The trypsin concentration is substantially higher than the inhibitor concentration. What is the…

A: Trypsin is a pancreatic protease which helps in the digestion of proteins. Trypsin is secreted in…

Q: What is the dominant biochemical activity or molecular interaction that Sickle Cell Anemia…

A: Hemoglobin is an oligomeric conjugated protein with four peptide chains joined by a…

Q: When comparing two or more ligands, a larger numerical value for KD corresponds to a higher binding…

A: “Since you have asked multiple question, we will solve the first question for you. If youwant any…

Q: Which of the following mechanisms of reversible enzyme inhibition describe the mode of action of…

A: Inhibition are of different type. They are mainly divided two; Reversible and Irreversible…

Q: Can wearing a mask, limiting public spaces capacity, and having travel restrictions be justified…

A: Covid 19 (Coronavirus disease 2019) is an infectious viral disease caused by SARS-CoV-2 (Severe…

Q: The synthetic equivalent of neuro pharmacologically active peptides obtained from the marine snail…

A: The synthetic equivalent of neuro pharmacologically active peptides obtained from the marine snail…

Q: Antithrombin III forms an irreversible complex with thrombin but not with prothrombin. What is the…

A: The blood cell is also called a hematopoietic cell. It is produced by the process named…

Q: TPA protein function. Use at least two sentences to describe the function of the TPA protein.

A: BASIC INFORMATION BIOMOLECULES These are the molecules that are made up of the biological elements…

Q: Atanzavir inhibits HIV-protease by mimicking the transition state of the hydrolysis reaction true…

A: HIV protease is a protease enzyme which cleaves the GAG(glycosaminoglycan) and GAG polypeptides to…

Q: 33. Which of the following statements is true about chemokines such as CXCL-8? A. They are powerful…

A: IL-8 is an important cytokine for inflammation which has the following effects:- Plays an…

Q: Sigma-32 is probably an autoregulator. Why and how?

A: Introduction In bacteria, a sigma factor is a protein required for transcription initiation. It is a…

Q: Briefly describe about allosteric effect of a drug, explain allosteric effect with an example

A: In biochemistry, allosteric regulation is the binding of an effector molecule to a location other…

Q: List the advantages of recombinant insulin.

A: Insulin is a natural hormone secreted by the endocrine cells of the pancreas. The function of…

Q: Provide a detailed arrow-pushing mechanism for the following transformation: Br H20 O- H3C Upload an…

A: Secondary Alkyl halides with water shows SN1 mechanism because water is a polar protic molecule.

Q: who is most at risk of shiver illness from covid-19?

A: Coronavirus disease is caused by SARS CoV-2 virus. The virus affects the respiratory system that…

Q: GTPYS is a nonhydrolyzable analog of GTP. Suppose this compound were added to a cell-free system…

A: The enzymes are known to break the nucleotides, which act as an essential step in several…

Q: Using the data in the first and third columns of the table, determine the type of inhibition that…

A: Enzyme inhibition works by preventing the activity of the enzyme, or by decreasing the production of…

Concept explainers

Immune Disorders

The collaboration between the cells and proteins that work together as a defense system against infection comprises the immune system.Each of them performs a variety of tasks to recognize and/or react against a foreign body.

Question

The proline isomerase activity of FK506 is
central to its mechanism of action as an
inhibitor of the immune system response.
* True
* False

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

give correct option. Polyisocyanates are involved in the induction of the full spectrum of hypersensitivity responses and nonimmune inflammatory reactions including asthma. Which of the following statement is not correct with respect to these observations and impact on immunity? a. A person once sensitized to polyisocyanate can demonstrate group reactivity to this set of compounds. b. Individuals having an acute exposure to toluene diisocyanate is more likely to develop hypersensitivity then individuals chronically exposed to low vapor levels. c. A mechanism for this hypersensitivity is the toluene diisocyanate forms a covalent bond with proteins that are part of the airway resulting in the immune system developing a response to “self” proteins. d. Adaptive immunity can interact or “message” the Innate immune system to up or down regulate its expression. e. All of the statements are correct.
What is meant by the term “affinity maturation” and what is its significance in the human immune system?
Why is it important to measure the pharmacokinetics(PK) and metabolism of an antibody drug
Which of the following statements is true? O Streptolysin-O is a growth factor for white blood cells. O Anti-streptolysin-O antibodies peak several months after initial symptoms. O Currently, the main method for detecting anti-streptoryan-G antibodies in radal immansattfo O Streptolysin-O does not induce an immune response. In the classical method of testing for anti-streptolysin-O antibodies, a positive reaction is indica intact red blood cells
It was mentioned to do Biocompatibility Testing to ensure the TPU scaffold and encapsulated beta cells won't trigger an immune response or adverse reactions. Can you explain the testing process in more detail please.
True/False: The antibody protein has two functional domains, one for antigen binding and a second to confer specific effector functions. These two functional domains are encoded by the antibody light chain and antibody heavy chain polypeptides, respectively.
Why would attaching an enediyne- containing molecule to an antibody be an attractive way to treat cancer cells?
All of the following are characteristics of defensins except: A. There are two classes of defensins B. They require high ionic strength to become active C. They have low variability and are highly conserved D. They have broad antimicrobial properties E. They lead to ionic burst
Would the same procedure done in Minimum Inhibitory Concentration (MIC) be applicable in determining allergies in man?
Hemophiliacs who lack factor IX are sometimes given infusions of factor VII to restore normal blood clotting activity. Explain.
It is often helpful to draw a complicated pathway in the form of a flow chart to visualize the multiple steps and the ways in which the steps are connected to each other. Draw the antibody-mediated immune response pathway that acts in response to an invading virus.
"To guarantee that the antigen-presenting cells in the thymus will display a complete repertoire of self peptides to allow elimination of self-reactive T cells, the thymus recruits dendritic cells from all over the body is true or false.