Type in response to each notes/questions The two strands of DNA are held together bybonds, but can be denatured byandThe nucleotides are linked together at backbone by.bonds which are much strongerand require ATP driven enzymeto break and create them.Replication/elongation of daughter strands occurs in the(opposite) to the parent/template strand.During TXN, the template is read in theDuring TLN, the polypeptide is synthesized in theorientation and isorientation.orientation.Describe how telomeres can be added. Why do they need to be addedDescribe replication licensing.Describe synthesis mechanism of leading (continuous) vs lagging strands (discontinuous). How are they similar anddifferent. What are the players involved.What do the following do?HelicaseGyraseLigaseTopoisomeraseprimaseDNA PolymeraseProkaryotic vs eukaryoticI, III, 8, ɛ, Y, nRNA Polymerase I, II, III and RNAPProkaryotic vs eukaryoticDNA can be damaged in a number of ways. For example, depurination is the hydrolysis ofbondsgroups. This type of damage can be repaired by cutting out that abasic(enzyme), filling in the gap with DNA Polymerase(euks), and then ligating the new nucleotide to the backbone withbetweenandnucleotide from the backbone with_(bact), or(enzyme), which forms abond.Which of the following depends on complementary base pairing?a. DNA replicationb. Transcriptionc. Translationd. Both a and be. All of the aboveRNA molecules that act as catalysts are calleda. ribozymes.b. glycosidic linkages.c. chaperonins.d. disulfide bridges.CS Scanned with CamScanner e. triglycerides.What nucleotides would you expect in repeats in a sequence that needs to dissociate easily (e.g., replication originsite)? Would you expect a higher or lower Tm with increasing replication sites?Define the following termsRho (p) factorSigma (6) factorIRESBranchpointSpliceosomesSNRNPS (aka smurfs)EJCIdentify the targets for the following targeting signalsNESNLSKDELSKLMannose 6 phosphateWhat are the different kinds of DNA damage. How might they be dealt with, or repaired?What are the differences between DNA and RNA polymerases?Describe the adventures of a primary mRNA transcript to full maturity. How might it be processed before it canbe a worthy template for polypeptide synthesis.Be able to describe the steps involved in DNA replicationBe able to describe the steps involved in transcription and translationDescribe splicing-spliceosomesDescribe how operons work.What can you tell me about the repressible operons. Inducible operons?What is an effector?Under what circumstance(s) is/are the lac operon genes expressed?Under what circumstance(s) is/are trp operon genes expressed?Describe epigenetic changes.What happens to gene activity when DNA is methylated?What happens to gene activity when histones are acetylated?CS Scanned with CamScanner

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The two strands of DNA are held together by. bonds, but can be denatured by and The nucleotides are linked together at backbone by bonds which are much stronger and require ATP driven enzyme to break and create them.