To be metabolized, glucose must be converted to glucose 6-phosphate. However, the phosphorylation of glucose to form glucose 6-phosphate is endergonic with a positive AG. How do cells circumvent this problem? The reaction is catalyzed by an enzyme, which allows the reaction to proceed by lowering its activation energy. An enzyme raises the activation energy barrier to favor glucose 6-phosphate formation. The reaction is catalyzed by an enzyme, which allows the reaction to proceed by changing its AG. An enzyme changes the equilibrium constant for the reaction to favor glucose 6-phosphate formation. The reaction is coupled to the hydrolysis of ATP, making the entire process exergonic.

To be metabolized, glucose must be converted to glucose 6-phosphate. However, the phosphorylation of glucose to form glucose 6-phosphate is endergonic with a positive AG. How do cells circumvent this problem? The reaction is catalyzed by an enzyme, which allows the reaction to proceed by lowering its activation energy. An enzyme raises the activation energy barrier to favor glucose 6-phosphate formation. The reaction is catalyzed by an enzyme, which allows the reaction to proceed by changing its AG. An enzyme changes the equilibrium constant for the reaction to favor glucose 6-phosphate formation. The reaction is coupled to the hydrolysis of ATP, making the entire process exergonic.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 20P: Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy...

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