Total fingerprint ridge count exemplifies a polygenic inheritance pattern.  Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow.  Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count.  Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females. Predict the TRC for each of the following individuals:   Genotype Male Female AABBCCDD     AabbccDd     AaBBCcDD     aaBbCCDd     A. Write the genotypes of parents who are heterozygous for all four genes. B. Write the genotype of their child who has the maximum number of active alleles possible. C. What are the TRCs for the parents? D. What is the TRC of the child from B (assume male)? Calculate the probability of two heterozygous (all 4 gene loci) parents producing a child with the minimum number of active alleles.  Type the answer as a fraction (x/y).

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Chapter5: The Inheritance Of Complex Traits
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Total fingerprint ridge count exemplifies a polygenic inheritance pattern.  Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow.  Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count.  Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females.

Predict the TRC for each of the following individuals:

 

Genotype

Male

Female

AABBCCDD

 

 

AabbccDd

 

 

AaBBCcDD

 

 

aaBbCCDd

 

 

A. Write the genotypes of parents who are heterozygous for all four genes.

B. Write the genotype of their child who has the maximum number of active alleles possible.

C. What are the TRCs for the parents?

D. What is the TRC of the child from B (assume male)?

Calculate the probability of two heterozygous (all 4 gene loci) parents producing a child with the minimum number of active alleles.  Type the answer as a fraction (x/y).

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