Treatment of a polypeptide with 2-mercaptoethanol yields two polypeptides with the following primary structures: Val-Met-Tyr-Ala-Cys-Ser-Phe-Ala-Glu-Ser Ser-Cys-Phe-Lys-Cys-Trp-Lys-Tyr-Cys-Phe-Arg-Cys-Ser Treatment of the original intact polypeptide with chymotrypsin yields the following peptides: 1. Ala, Glu, Ser 3. Tyr, Val, Met 5. Ser, Phe, 2 Cys, Lys, Ala, Trp 2. 2 Phe, 2 Cys, Ser 4. Arg, Ser, Cys 6 Tyr, Lys Determine the positions of the disulfide bridges in the original polypeptide.

Treatment of a polypeptide with 2-mercaptoethanol yields two polypeptides with the following primary structures: Val-Met-Tyr-Ala-Cys-Ser-Phe-Ala-Glu-Ser Ser-Cys-Phe-Lys-Cys-Trp-Lys-Tyr-Cys-Phe-Arg-Cys-Ser Treatment of the original intact polypeptide with chymotrypsin yields the following peptides: 1. Ala, Glu, Ser 3. Tyr, Val, Met 5. Ser, Phe, 2 Cys, Lys, Ala, Trp 2. 2 Phe, 2 Cys, Ser 4. Arg, Ser, Cys 6 Tyr, Lys Determine the positions of the disulfide bridges in the original polypeptide.

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins

Section26.6: Peptide Sequencing: The Edman Degradation

Problem 15P: Give the amino acid sequence of hexapeptides that produce the following sets of fragments upon...

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