Trichothiodystrophy is a human inherited disorder characterized by premature aging, including osteoporosis, osteosclerosis, early graying, infertility, and reduced life span. The results of studies showed that the mutation that causes this disorder occurs in a gene that encodes a DNA helicase. Propose a mechanism for how a mutation in a DNA helicase might cause premature aging. Be sure to relate the symptoms of the disorder to possible functions of the helicase enzyme.

Question

Trichothiodystrophy is a human inherited disorder characterized by
premature aging, including osteoporosis, osteosclerosis, early graying,
infertility, and reduced life span. The results of studies showed that the
mutation that causes this disorder occurs in a gene that encodes a DNA
helicase. Propose a mechanism for how a mutation in a DNA helicase
might cause premature aging. Be sure to relate the symptoms of the
disorder to possible functions of the helicase enzyme.

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