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StatisticsQ&A Libraryuse the Wilcoxon rank-sum test.Clinical Trials of Lipitor The sample data below are changes in LDL cholesterol levels in clinical trials of Lipitor (atorvastatin). It was claimed that Lipitor had an effect on LDL cholesterol. (The data are based on results given in a Parke-Davis memo from David G. Orloff, M.D., the medical team leader for clinical trials of Lipitor. Pfizer declined to provide die author with the original data values.) Negative values represent decreases in LDL cholesterol. Use a 0.05 significance level to test the claim that for those treated with 20 mg of atorvastatin and those treated widi 80 mg of atorvastatin, changes in LDL cholesterol have the same median. What do the results suggest?Group treated with 20 mg of atorvastatin:−28 −32 −29 −39 −31 −35 −25 −36 −35 −26 −29 −34 −30Group treated with 80 mg of atorvastatin:−42 −41 −38 −42 −41 −41 −40 −44 −32 −37 −41 −37 −34 −31Question

Asked Feb 18, 2020

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use the Wilcoxon rank-sum test.

Clinical Trials of Lipitor The sample data below are changes in LDL cholesterol levels in clinical trials of Lipitor (atorvastatin). It was claimed that Lipitor had an effect on LDL cholesterol. (The data are based on results given in a Parke-Davis memo from David G. Orloff, M.D., the medical team leader for clinical trials of Lipitor. Pfizer declined to provide die author with the original data values.) Negative values represent decreases in LDL cholesterol. Use a 0.05 significance level to test the claim that for those treated with 20 mg of atorvastatin and those treated widi 80 mg of atorvastatin, changes in LDL cholesterol have the same median. What do the results suggest?

Group treated with 20 mg of atorvastatin:

−28 −32 −29 −39 −31 −35 −25 −36 −35 −26 −29 −34 −30

Group treated with 80 mg of atorvastatin:

−42 −41 −38 −42 −41 −41 −40 −44 −32 −37 −41 −37 −34 −31

Step 1

Given sample data of changes in LDL cholesterol levels in clinical trails of Lipitor. The combined sample of 27 values are assigned ranks in order that the least value will be rank 1, the second least will be rank 2 and so on. If there is a tie then mean of their ranks is found and each value is assigned the mean rank as shown below

here you can see 12(least absolute value) is assigned as rank 1 and next least absolute value is assigned as rank 2 and so on and highest absolute value 44 is assigned 27 rank.

Considering changes in LDL cholesterol levels of group treated with 20 mg of Atorvastatin as sample 1 and 80 mg of Ator...

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