Voles (Microtus ochrogaster) were trapped in fields in southem Indiana and genotyped for a locus that encodes transferrin (a blood protein). The following numbers of genotypes were recorded, where T and T represent different alleles. [Tom McHugh/Science Source.] TETE TET; TFT; 407 170 17 Calculate the genotypic and allelic frequencies of the transferrin locus for this population.
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- In Figure 6-21, propose a specific genetic explanationfor individual Q (give a possible genotype, defining theallelesIntroduction: A person’s blood type is an inherited trait governing special marker proteins appear-ing on the surface of their red blood cells. Blood typing is important, because it governs who anindividual can give or receive blood donations from; blood with proteins markers not present in theirown blood will be rejected by an individual’s immune system.There are two separate genes that govern blood type; the ABO gene has two dominant options, Aand B, and a recessive option called O. For example, an individual with AO or AA would presentthe A protein, and an individual with AB will present both the A and B proteins on their blood;an individual with OO has no proteins from this gene. The Rh gene has two options; the dominantoption is called positive (or + for short), while the recessive option is called negative or null (or –for short). For example, an individual with ++ or +– would present the Rh protein on their blood,while an individual with – – would not present the Rh…Introduction: A person’s blood type is an inherited trait governing special marker proteins appear-ing on the surface of their red blood cells. Blood typing is important, because it governs who anindividual can give or receive blood donations from; blood with proteins markers not present in theirown blood will be rejected by an individual’s immune system.There are two separate genes that govern blood type; the ABO gene has two dominant options, Aand B, and a recessive option called O. For example, an individual with AO or AA would presentthe A protein, and an individual with AB will present both the A and B proteins on their blood;an individual with OO has no proteins from this gene. The Rh gene has two options; the dominantoption is called positive (or + for short), while the recessive option is called negative or null (or –for short). For example, an individual with ++ or +– would present the Rh protein on their blood,while an individual with – – would not present the Rh…
- . For several years, Hans Nachtsheim investigated an inherited anomaly of the white blood cells of rabbits. Thisanomaly, termed the Pelger anomaly, is the arrest ofthe segmentation of the nuclei of certain white cells. Thisanomaly does not appear to seriously burden the rabbits.a. When rabbits showing the Pelger anomaly were matedwith rabbits from a true-breeding normal stock,Nachtsheim counted 217 offspring showing the Pelgeranomaly and 237 normal progeny. What is the geneticbasis of the Pelger anomaly?b. When rabbits with the Pelger anomaly were matedwith each other, Nachtsheim found 223 normal progeny,439 with the Pelger anomaly, and 39 extremely abnormalprogeny. These very abnormal progeny not only haddefective white blood cells, but also showed severedeformities of the skeletal system; almost all of themdied soon after birth. In genetic terms, what do yousuppose these extremely defective rabbits represented?Why were there only 39 of them?c. What additional experimental evidence…In a large, randomly mating population, the frequency of the allele (s)for sickle-cell hemoglobin is 0.028. The results of studies have shownthat people with the following genotypes at the beta-chain locus producethe following average numbers of offspring:Genotype Average numberof offspring producedSS 5Ss 6ss 0a. What will the frequency of the sickle-cell allele (s) be in the nextgeneration?b. What will the frequency of the sickle-cell allele be at equilibrium?The A and B antigens in humans may be found in water-soluble form in secretions,including saliva, of some individuals (Se/Se and Se/se) but not in others (se/se). The populationthus contains “secretors” and “nonsecretors.”(a) Determine the proportion of various phenotypes (blood type and ability to secrete) in matingsbetween individuals that are blood type AB and type O, both of whom are Se/se.(b) How will the results of such matings change if both parents are heterozygous for the genecontrolling the synthesis of the H substance (Hh)?
- Identify each of the following as an example of allele, genotype,and/or phenotype frequency:A. Approximately 1 in 2500 individuals of Northern Europeandescent is born with cystic fibrosis.B. The percentage of carriers of the sickle cell allele in WestAfrica is approximately 13%.C. The number of new mutations per generation resultingin achondroplasia, a genetic disorder, is approximately5 × 10−5.In the ABO blood group system, what phenotype(s) could the offspring have if the parents' genotypes are IBIB XIAIO?. Consider the genotypes of two lines of chickens: thepure-line mottled Honduran is i/i ; D/D ; M/M ; W/W, andthe pure-line leghorn is I/I ; d/d ; m/m ; w/w, whereI = white feathers, i = colored feathersD = duplex comb, d = simplex combM = bearded, m = beardlessW = white skin, w = yellow skinThese four genes assort independently. Starting withthese two pure lines, what is the fastest and mostconvenient way of generating a pure line that has coloredfeathers, has a simplex comb, is beardless, and has yellowskin? Make sure that you showa. the breeding pedigree.b. the genotype of each animal represented.c. how many eggs to hatch in each cross, and why thisnumber.d. why your scheme is the fastest and the mostconvenient