What can cause mutations in the DNA sequence? Select all that apply. A. Failure of repair enzymes to recognize mismatched nucleotides before and during DNA replication B. Recognition of mismatched bases by repair enzymes before and during DNA replication C. Exposure of cells to ionizing radiation D. Nucleotide errors occurring during DNA replication

What can cause mutations in the DNA sequence? Select all that apply. A. Failure of repair enzymes to recognize mismatched nucleotides before and during DNA replication B. Recognition of mismatched bases by repair enzymes before and during DNA replication C. Exposure of cells to ionizing radiation D. Nucleotide errors occurring during DNA replication

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter9: Molecular Biology

Section: Chapter Questions

Problem 5RQ: The initial mechanism for repairing nucleotide errors in DNA is _____. a. mismatch repair b. DNA...

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What can cause mutations in the DNA sequence? Select all that apply. a.Exposure of cells to ionizing radiation b.Failure of repair enzymes to recognize mismatched nucleotides before and during DNA replication c.Recognition of mismatched bases by repair enzymes before and during DNA replication d.Nucleotide errors occurring during DNA replication
Nucleotide excision repair A. recognizes and repairs thymine dimers and other damaged bases in DNA B. corrects errors in nucleotide excision C. recognizes and removes mismatched bases after DNA synthesis is completed D. removes nucleotides that are incorrectly incorporated during DNA synthesis
What is DNA polymerase? a.An enzyme that carries out DNA replication b.Short, single strand of DNA that base-pairs with a specific DNA sequence c.An enzyme that corrects mutations that arise during the replication of DNA d.An enzyme that seals any gaps that remain between bases of replicating strands of DNA
Why are mutations more likely to occur in repeated DNA sequences? a. These bases are unstable b. bases in the strand can form base pairs, generating loops that interfere with replication and repair enzymes. c. The repeats hold onto the replication enzymes, causing base mismatches d. the repeats attract and bind to mutagens, increasing the mutation rate
Base analogs are mutagenic because of which characteristic? a. They produce changes in DNA polymerase that cause it to malfunction. b. They distort the structure of DNA. c. They are similar in structure to the normal bases. d. They chemically modify the normal bases.
(a) What is the function of helicase in DNA replication?(b) What is the function of DNA polymerase?(c) What are replication forks? Compare and contrast leading and lagging strands. Answer all please
In the dideoxy-sequencing reaction, what terminates DNA synthesis at a particular base? a. The absence of a base on the ddNTP halts the DNA polymerase. b. The ddNTP causes a break in the sugar–phosphate backbone. c. DNA polymerase will not incorporate a ddNTP into the growing DNA strand. d. The absence of a 3′-OH group on the ddNTP prevents the addition of another nucleotide.
The initial mechanism for repairing nucleotide errors in DNA is ________. a. mismatch repair b. DNA polymerase proofreading c. nucleotide excision repair d. thymine dimers
Why is DNA replication considered semiconservative? A. Both strands of each replicating DNA molecules are conserved. B. One molecule consists of the old strands and the other DNA molecule is entirely new. C. One strand of each replicating DNA molecule is conserved and the other strand is newly synthesized. D. Both strands of each replicating DNA molecule are new.
DNA damage by uv light creates pyrimidine dimers between adjacent pyrimidines on the same strand. The cellular mechanism used to repair these dimers is : A. Mismatch repair B. Proofreading C. Nucleotide Excision Repair D. Single- base excision
DNA strands are anti-parallel and DNA polymerase can only synthesize DNA in a 5' to 3' direction. How does the enzyme synthesize both strands at the same time? A. The leading strand is sythesised in Okazaki fragments B. The lagging strand is synthesised in short Okazaki fragments. C. Only one strand is replicated. D. There are more than one DNA polymerase involved.
When does spontaneous mutation occur? A. a DNA base is an unstable tautomeric form as the replication fork arrives and a mismatched base is inserted B. thymine temporarily becomes uracil C. the sugars and phosphates in the DNA double helix exchange places D. a person smokes cigarettes or is exposed to a teratogen