What condition could cause the bloodstream to be hypertonic relative to the nephron?

Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter5: Urinalysis
Section5.2: Urine Collection And Processing
Problem 8RQ
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What condition could cause the bloodstream to be hypertonic relative to the nephron?

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