Asked Jul 30, 2019

What makes hypervariable region I (HVRI) within mtDNA useful for researchers studying continental patterns of human migration?


Expert Answer

Step 1

A hypervariable region (HVR) refers to a site within the D loop of mitochondrial DNA (mtDNA) or the nuclear DNA in which mutations (repeats or substitutions) occur more rapidly compared to other regions. In the hypervariable region changes or repeats are highly polymorphic in nature.

Step 2

mtDNA has two main parts, namely the control region and the coding region. The control region is frequently termed as hypervariable region. In mtDNA, there are two HVR: HVR1 and HVR2. The HVR1 runs from nucleotide 16001- nucleotide 16569. The rate of mutation in HVR is a hundred times greater compared to the nuclear genome. The low-resolution capacity of HVR 1 within mtDNA is more useful for researchers to study the continental patterns of human migration. 

For example, if two persons have the same mutations within the HVR1, then the match is said to be low resolution. When the perso...

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