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What would be the effect on the cell cycle of a drug that inhibited each
of the following?
a. MPF
b. Cyclin-E–CDK
c. Cyclin-D–CDK
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- Part A and B A. What is the normal function of the Rb protein? A) Rb prevents the cell cycle from proceeding unless the cell is prepared to do so B) Rb causes cells to undergo apoptosis C) Rb promotes Cdk activation D) Each of the other selections is true E) Rb repairs damaged DNA B. How do tumors arise? A) When cell proliferation occurs at a higher rate than cell death B) When someone is infected with a tumor from another person C) When cell death occurs at a very high rate D) When cell proliferation occurs at a very low rateWhy is a rapidly growing tissue, such as the root tip of a plant, a good model for studying the effects of a drug on cell division?What happens to microtubules in the presence of very high levels of GTP? A. They will undergo treadmilling B. They will grow rapidly C. They become unstable and may undergo catastrophy D. They will shrink
- You have a cell with a mutated and abnormal p53 protein. Which of the following will be affected in that cell? a. Apoptosis b. DNA repair c. Ability to arrest/pause the cell cycle 1. a,b and c 2. a & b 3. a&c 4. b onlyWhat is the role of executioner proteins in apoptosis?a. They kill the cell by destroying its proteins.b. They function as the “death receptors” on the surface of the cell.c. They are part of the immune response that eliminates the cells.d. They cause the cell to swell and burst.You remove cyclin from a cell during G2 a single time and then leave the cell alone. What is the consequence? Group of answer choices A. the cells exits mitosis into G1 B. the cell can never enter mitosis C. the cell immediately enters mitosis D. the cell's entry into mitosis is delayed
- How do Cyclins work? a. They are kinases that phosphorylate key proteins at different points in the cell cycle. b. They are transcription factors that regulate the transcription of genes required at different stages of the cell cycle. c. They stop progression of cells through the cell cycle. d. They bind and activate kinases related to progress through the cell cycle.In eukaryotic cells, which occurs during the prophase of mitosis? A. appearance of the nuclear envelope B. breakup of the nuclear envelope C. replication of DNA D. separation of sister chromatids E. duplication of chromatidsWhich could lead to uncontrolled growth in cancer? A. A nonfunctional E2F protein B. The overexpression of MPF activity C. A nonfunctional Rb protein D. The overexpression of G1 cyclin
- Cells that DO NOT divide or participate in the cell cycle are usually arrested in what phase? a. S phase b. Prophase c. G2 d. G0 e. M phaseWhich molecule is a Cdk inhibitor that is controlled by p53? a. cyclin b. anti-kinase c. Rb d. p21The decline of MPF activity at the end of mitosis is due to a. an increase in the cell's volume to genome ratio b. the destruction of the protein kinase Cdk c. decreased sythesis of cyclin d. The degradation of cyclin