. Which observation suggested to Sutherland the involvementof a second messenger in epinephrine’s effect on liver cells?(A) Enzymatic activity was proportional to the amount ofcalcium added to a cell-free extract.(B) Receptor studies indicated that epinephrine was a ligand.(C) Glycogen breakdown was observed only when epinephrinewas administered to intact cells.(D) Glycogen breakdown was observed only when epinephrineand glycogen phosphorylase were mixed.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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. Which observation suggested to Sutherland the involvement
of a second messenger in epinephrine’s effect on liver cells?
(A) Enzymatic activity was proportional to the amount of
calcium added to a cell-free extract.
(B) Receptor studies indicated that epinephrine was a ligand.
(C) Glycogen breakdown was observed only when epinephrine
was administered to intact cells.
(D) Glycogen breakdown was observed only when epinephrine
and glycogen phosphorylase were mixed.

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