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- Match the terms with the most suitable description. ___ methylation a. makes a man out of you ___ SRY gene b. binding site for repressor ___ operator c. cells become specialized ___ Barr body d. can be epigenetic ___ differentiation e. inactivated X chromosomeUnder what condition might a human male have the XX sex chromosome complement? It is not possible. She has an X chromosome lacks an active Xist gene. He has an X chromosome that carries an SRY gene. He has a mutation that renders the SOX9 gene non-functional. He has a mutation that renders the SRY gene non-functional.With the given frequency, construct a chromosome map. Arrange the sequence correctly. Write the letters as shown in the example (ex. ABCD). Frequency: M-A: 10%; M-Y: 2%, L-A: 2%; and Y-L: 6%
- During X chromosome inactivation,______ . a. female cells shut down b. RNA sticks to a chromosome c. pigments formWhich of the following statements is INCORRECT? Synapsis of the X and Y chromosomes in males occurs only at the pseudoautosomal regions. Genes in the pseudoautosomal regions on the Barr body X chromosome escape inactivation. Nonhomologous regions of the X and Y chromosome condense to form a sex vesicle during leptotene. Although one of the two X chromosomes in XXY males becomes a Barr body, XXY males have three doses of the genes in the PAR regions.Which of the following is a type of genetic change that may producean oncogene?a. Missense mutationb. Gene amplificationc. Chromosomal translocationd. All of the above may produce an oncogene.
- Why is X chromosome inactivation important in female cells? (300 word limit)On rare occasions, a chromosome can suffer a small deletionthat removes the centromere. When this occurs, the chromosome usually is not found within subsequent daughter cells.Explain why a chromosome without a centromere is not transmitted very efficiently from mother to daughter cells. (Note: Ifa chromosome is located outside the nucleus after telophase, itis degraded.)In fruit flies, dosage compensation is achieved bya. X-chromosome inactivation.b. doubling the expression of genes on the single X chromosome in the male.c. decreasing the expression of genes on the two X chromosomes by 50% in the female.d. all of the above.
- A color-blind, chromatin-positive male child (one Barr body) has a maternal grandfather who was color blind. The boy’s mother and father are phenotypically normal. Construct and support (using appropriately labeled diagrams) a rationale whereby the chromosomal and genetic attributes of the chromatin-positive male are fully explained.With the given frequency, construct a chromosome map. Arrange the sequence correctly. Write the letters as shown in the example (ex. ABCD). Frequency: N-C: 8%; N-I: 3%; and I-C: 1%Which of the following can lead to cancer?a. smokingb. pollutionc. mutations of Rb and p53d. All of the above.
